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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Neurobiol Dis. 2011 Jun 25;44(1):73–83. doi: 10.1016/j.nbd.2011.06.006

Figure 5. Netrin-1 gene transfer enhances post-stroke locomotor activity, improves exploratory behavior and reduces ischemia-induced motor asymmetry in limb usage.

Figure 5

MCAO rats that received AAV-Netrin-1 gene transfer displayed increased movement, compared to those that received AAV-LacZ (B) over 3 days in the novel open field test (*: p<0.05). The AAV-Netrin-1 MCAO rats also had a tendency to move greater distances (p=0.13) (A), spend more time being active (*: p<0.05), and spend less time resting (**: p<0.01) (C). MCAO rats that received AAV-Netrin-1 gene transfer spent less rest time in the corner zone compared to those that received AAV-LacZ (D) (*: p<0.05). The AAV-Netrin-1 group spent more time resting in the center zone as the days progressed, a sign of being less anxious (Z2 rest: treatment × zone interaction: p=0.06) (E). Netrin-1 gene transfer decreased the favoring use of the unaffected limb after MCAO (*: p<0.05) and increased the use of the affected limb (*: p<0.05) during exploratory activity in a cylinder (F). There was no significant difference in the simultaneous use of the forelimbs between groups (p>0.2). D1, D2 and D3 in X-axis represent consecutive days of testing.