Benzofuranone ring substituted noscapine analogs exhibit significant inter-line variability. A, B, C, D and E are the plots of percent cell survival versus concentration of noscapine analogs for cancer cells from varying tissue origins viz., lung (A549), lymphoma (CEM), breast (MCF-7), pancreas (MIA PaCa-2) and prostate (PC-3) used for determination of IC50 values. F is a bar-graph representation of IC50 values of noscapine analogs in various cancer cells used in our study. The values and error bars shown in the graphs represent average and standard deviations, respectively, of three independent experiments (p <0.05).