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In vitro cytotoxicity (IC50, µM) of noscapine analogs
| Compound | R | Cancer cell line, IC50 (µM) | ||||
|---|---|---|---|---|---|---|
| A549 | CEM | MCF-7 | MIA PaCa-2 | PC-3 | ||
| 3 | -COMe | 3.2 | 15.5 | 166.0 | 1.0 | 9.3 |
| 4 | -COPh | 4.5 | 49.0 | 34.0 | 1.7 | 4.8 |
| 5 | -CONHEt | 5.6 | 1.7 | 49.0 | 49.0 | 6.6 |
| 6 | -CONHPh | 50.0 | 250.0 | 182.0 | 1.0 | 83.2 |
| 7 | -CONHBn | 25.0 | 7.1 | 74.1 | 24.5 | 49.0 |
| Noscapine | 73.0 | 20.0 | 45.0 | 70.0 | 51.0 | |
