Table 2.
Variants showing association (uncorrected P-value) with type 2 diabetes and obesity.
| Trait | Gene | SNP | Allele (major/minor) |
MAF (affected/unaffected) |
OR (95% CI) | P |
|---|---|---|---|---|---|---|
| Type 2 diabetes (total study population: 1019 cases versus 1006 controls)† | MTHFR | rs1801133 | C/T | 0.18/0.21 | 0.78 (0.67–0.92) | 0.003 |
|
| ||||||
| Type 2 diabetes (Normal weight subjects: 290 cases versus 436 controls)† | MTHFR | rs1801133 | C/T | 0.18/0.21 | 0.62 (0.46–0.85) | 0.002 |
| MTHFR | rs9651118 | C/T | 0.26/0.25 | 1.31 (1.01–1.68) | 0.04 | |
| CHDH | rs4563403 | G/A | 0.10/0.11 | 0.66 (0.45–0.95) | 0.02 | |
| CBS | rs706208 | T/C | 0.41/0.39 | 1.30 (1.03–1.63) | 0.03 | |
| MTHFD1L | rs1555179 | C/T | 0.26/0.23 | 1.36 (1.04–1.78) | 0.03 | |
|
| ||||||
| Type 2 diabetes (Obese/over-weight subjects: 691cases versus 562 controls)† | MTHFD1 | rs1076991 | A/G | 0.40/0.44 | 0.81 (0.69–0.95) | 0.01 |
| TCN2 | rs1801198 | G/C | 0.42/0.44 | 0.85 (0.72–0.99) | 0.04 | |
|
| ||||||
| Obesity (562 Obese/over-weight versus 436 normal weights)‡ | CHDH | rs4563403 | G/A | 0.09/0.13 | 0.69 (0.52–0.92) | 0.01 |
| TCN2 | rs1801198 | G/C | 0.46/0.41 | 1.24 (1.04–1.48) | 0.02 | |
| MTR | rs16834521 | T/C | 0.31/0.35 | 0.82 (0.68–0.99) | 0.04 | |
†Analyses adjusted for sex, age, and BMI. ‡Analysis performed only in control subjects and adjusted for sex and age, MAF: minor allele frequency, OR: odds ratio, CI: confidence interval.