Table 3.
Association of rs1801133 with all traits in initial phase, replication phase, and meta-analysis.
| Trait | Initial phase | Replication phase | Meta-analysis | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR/β(95% CI) | P | OR/β (95% CI) | P | P f | P r | ORf/β f | ORr/β r | Q | I | |
| Type2 diabetes (all) † | 0.78 (0.67–0.92) | 0.003 | 1.01 (0.87–1.19) | 0.86 | 0.05 | 0.38 | 0.90 | 0.89 | 0.024 | 80.44 |
| Type2 diabetes (NW) † | 0.62 (0.46–0.85) | 0.002 | 1.11(0.80–1.54) | 0.53 | 0.07 | 0.52 | 0.81 | 0.83 | 0.012 | 84.30 |
| Type2 diabetes (OW/OB) † | 0.86 (0.71–1.04) | 0.13 | 0.98 (0.82–1.17) | 0.85 | 0.25 | 0.25 | 0.93 | 0.93 | 0.32 | 0.25 |
| Obesity (NW versus OW/OB) ‡ | 1.07 (0.86–1.33) | 0.56 | 1.11 (0.86–1.43) | 0.42 | 0.33 | 0.33 | 1.09 | 1.09 | 0.82 | 0 |
| BMI‡ | 0.32 ((−0.19)–(−0.84)) | 0.22 | 0.25 (−0.26–0.76) | 0.34 | 0.12 | 0.12 | 0.29 | 0.29 | 0.84 | 0 |
| Weight‡ | 1.41 (0.02–2.80) | 0.05 | 0.43 (−0.95–1.81) | 0.54 | 0.07 | 0.07 | 0.92 | 0.92 | 0.33 | 0 |
| WC‡ | 0.47 (−0.76–1.70) | 0.45 | 0.28 (−1.12–1.68) | 0.70 | 0.41 | 0.41 | 0.39 | 0.39 | 0.84 | 0 |
| WHR‡ | −0.003 (−0.01–0.005) | 0.46 | −0.005 (−0.01–0.003) | 0.24 | 0.18 | 0.18 | −0.004 | −0.004 | 0.73 | 0 |
| FPG† | 0.55 (−0.66–1.77) | 0.37 | -0.83 (−2.14–0.47) | 0.21 | 0.84 | 0.86 | −0.09 | −0.12 | 0.13 | 56.98 |
| 2h PPG† | −5.06 ((−9.72)–(−0.40)) | 0.03 | −1.13 (−4.84–2.58) | 0.55 | 0.07 | 0.15 | −2.65 | −2.83 | 0.20 | 40.15 |
| HbA1c† | 0.02 (−0.03–0.07) | 0.41 | −0.03 (−0.07–0.01) | 0.15 | 0.58 | 0.79 | −0.009 | −0.007 | 0.12 | 59.73 |
| FPI† | 0.43 (−0.44–1.30) | 0.33 | −0.77 ((−1.42)–(−0.11)) | 0.02 | 0.21 | 0.73 | −0.33 | −0.20 | 0.03 | 78.49 |
| HOMA-IR† | 0.11 (−0.09–0.31) | 0.30 | −0.20 ((−0.36)–(−0.04)) | 0.01 | 0.21 | 0.73 | −0.08 | −0.05 | 0.02 | 81.77 |
| HOMA-B† | 70.25 (−34.99–175.50) | 0.19 | −652.8 ((−1165)–(−140.1)) | 0.01 | 0.44 | 0.49 | 41.02 | −245.94 | 0.0068 | 86.36 |
| HOMA-S† | −0.09 (−0.26–0.07) | 0.27 | 0.62 (0.13–1.11) | 0.01 | 0.82 | 0.53 | −0.02 | 0.23 | 0.0067 | 86.41 |
| C-peptide† | 0.01 (−0.10–0.12) | 0.86 | −0.07 (−0.17–0.04) | 0.22 | 0.44 | 0.44 | −0.03 | −0.03 | 0.32 | 0 |
| CRP† | −0.16 (−0.38–0.05) | 0.14 | −0.12 (−0.34–0.1) | 0.28 | 0.07 | 0.07 | −0.14 | −0.14 | 0.79 | 0 |
| HDL-C† | 2.14 (0.68–3.59) | 0.004 | −0.05 (−1.31–1.21) | 0.94 | 0.07 | 0.36 | 0.89 | 1.01 | 0.03 | 79.83 |
| LDL-C† | 3.25 (−0.32–6.81) | 0.07 | 2.61 (−1.03–6.26) | 0.16 | 0.02 | 0.02 | 2.94 | 2.94 | 0.81 | 0 |
| TC† | 5.61 (1.28–9.94) | 0.01 | 2.02 (−2.43–6.47) | 0.37 | 0.01 | 0.03 | 3.86 | 3.85 | 0.26 | 22.03 |
| TG† | 7.08 (−0.88–15.05) | 0.08 | −3.73 (−10.26–2.81) | 0.26 | 0.81 | 0.79 | 0.62 | 1.43 | 0.04 | 76.37 |
| Systolic BP† | 1.53 (−0.41–3.48) | 0.12 | −0.77 (−2.58–1.03) | 0.40 | 0.66 | 0.76 | 0.29 | 0.35 | 0.09 | 65.50 |
| Diastolic BP† | 0.77 (−0.30–1.85) | 0.16 | −0.74 (−1.82–0.35) | 0.18 | 0.95 | 0.98 | 0.02 | 0.02 | 0.05 | 73.47 |
| Creatinine† | 0.02 (−0.004–0.04) | 0.11 | −0.01 (−0.05–0.02) | 0.50 | 0.33 | 0.68 | 0.01 | 0.01 | 0.16 | 50.00 |
| Urea† | 0.28 (−0.63–1.20) | 0.54 | −0.12 (−1.14–0.9) | 0.82 | 0.76 | 0.76 | 0.10 | 0.10 | 0.57 | 0 |
| Uric acid† | 0.37 (−0.02–0.76) | 0.06 | 0.05 (−0.1–0.19) | 0.55 | 0.22 | 0.31 | 0.09 | 0.15 | 0.13 | 56.68 |
†Analyses adjusted for sex, age, and BMI.
‡Analysis performed only in control subjects and adjusted for sex and age.
OR: odds ratio, CI: confidence interval, P f: P value for fixed effect, P r: P value for random effect ORf: odds ratio for fixed effect, β f: beta value for fixed effect, ORr: odds ratio for random effect, β r: beta value for random effect, Q: P value for Cochrane's Q statistic, and I: I 2 heterogeneity index (0–100).