Table 5.
SNP and antibiotic resistance gene profiles of E. faecium isolates and their corresponding Sequence types (STs)
| SNP Profile | SNP ID | No. of Isolates | Antibiotic resistance [Identified genetic determinants] | Corresponding sequence Types (STs) for SNP profiles in MLST |
|---|---|---|---|---|
| AAACTTTC | 1 | 3 | No antibiotic resistance detected | ST 544, ST 583 |
| AACCCTTCa | 2 | 1 | Amp R [pbp5]m; Tet R [tetM] | ST 602 N |
| AACCCTTCa | 2 | 3 | Cip IR [gyrA] | |
| AACCCTTCa | 2 | 2 | No antibiotic resistance detected | |
| AATCCTTC | 3 | 1 | Gen IR [aac(6')-aph(2')]; Cip IR [gyrA] | ST8, ST9, ST58, ST134, ST194, ST198, ST237, ST244, ST248, |
| AATCCTTC | 3 | 2 | No antibiotic resistance detected | ST259, ST266, ST298, ST309, ST370, ST402, ST425, |
| AATCTTTC | 4 | 1 | No antibiotic resistance detected | ST40, ST100, ST163, ST211, ST221, ST223, ST226, |
| AGCCCCTC | 5 | 1 | Gen IR [aac(6')-aph(2')] | ST 607 N |
| AGCCCTCT | 6 | 1 | No antibiotic resistance detected | ST508 |
| AGCCCTTT | 7 | 2 | Cip IR [gyrA] | ST 603 N |
| AGCCCTTT | 7 | 1 | No antibiotic resistance detected | |
| AGCCTTTC | 8 | 2 | No antibiotic resistance detected | ST 604 N |
| AGCTCTCC | 9 | 2 | Gen IR [aac(6')-aph(2')];Cip R [gyrA]m;Amp R [pbp5]m | ST260, ST262, ST273, ST322 |
| AGTCCTTC | 10 | 2 | Gen IR [aac(6')-aph(2')]; Cip R [gyrA]m | ST13, ST14, ST48, ST79, ST82, ST120, ST157, ST195, ST200, ST241 |
| Tet R [tetL & S] | ST242, ST310, ST311, | |||
| AGTCCTTT | 11 | 1 | Gen IR [aac(6')-aph(2')]; Cip IR [gyrA] | ST15, ST70 |
| AGTCTTTT | 12 | 2 | Cip IR [gyrA] | ST 605 N |
| GACCCTCC | 13 | 1 | Gen IR [aac(6')-aph(2')] | ST 608 N |
| GACCCTCC | 13 | 1 | Cip IR [gyrA] | |
| GACCCTTT | 14 | 1 | Cip IR [gyrA]; Tet R [tetL & M] | ST 609 N |
| GACCCTTT | 14 | 2 | Tet R [tetL,M & S] | |
| GATCCTTC | 15 | 1 | Gen IR [aac(6')-aph(2')] | ST 610 N |
| GGCCCCCC | 16 | 2 | Cip IR [gyrA] | ST501, ST511, ST516, ST518, ST521, ST522, ST529, ST530, ST565, ST588, ST592, ST599 |
| GGCCCTCC | 17 | 3 | Amp R [pbp5]m; Tet IR [tetL & tetM] | ST162 |
| GGCCCTTC | 18 | 2 | Cip IR [gyrA] | ST 611 N |
| GGCCTCCC | 19 | 1 | No antibiotic resistance detected | ST 606 N |
| GGTCCCCC | 20 | 2 | Cip IR [gyrA] | ST22, ST23, ST24, ST27, ST28, ST33, ST36, ST55, ST59, ST106, |
| ST111, ST119, ST122, ST131, ST136, ST159, ST214, ST263, ST269, | ||||
| ST270, ST315, ST372, ST379, ST422, ST435 | ||||
| GGTCCTCC | 21 | 1 | Cip R [gyrA]m | ST1, ST2, ST3, ST4, ST32, ST34, ST35, ST41, ST43, ST72, |
| ST87, ST90, ST104, ST109, ST128, ST139, ST146, ST215, ST250, ST253 | ||||
| ST257, ST291, ST292, ST330, ST426, ST427, | ||||
| GGTCCTTT | 22 | 1 | Cip IR [gyrA] | ST6, ST88, ST149, ST170, ST247, ST255, ST354 |
| GGTCCTTC | 23 | 2 | No antibiotic resistance detected | ST7, ST21, ST25, ST26, ST29, ST37, ST57, ST66, ST68, ST83, |
| ST89,ST97,ST99,ST112,ST113,ST115,ST124, ST129, ST143, ST158, | ||||
| ST160, ST176, ST183, ST210, ST236, ST243, ST245, ST246, ST251, | ||||
| ST265, ST271, ST272, ST277, ST281, ST284, ST297, ST358, ST381, | ||||
| ST384, ST395, ST401, ST418, ST433, ST437, | ||||
aSNP profiles which were present in hospital isolates are bold and underlined
SNP profiles in bold text are isolates with the same SNP profiles but with different antibiotic resistant gene profiles.
Amp; ampicillin, Cip; ciprofloxacin, Gen; gentamicin, Tet; tetracycline,
R Resistant, IR Intermediate resistant, m mutation
N New sequence types identified in the present study