Figure 3.

Comparing sensitivity and specificity among the nine individual ortholog prediction tools and the integrative tool DIOPT. Comparing sensitivity and specificity using a manually assembled reference set (3a), or using the KOG human-specific gene set (3b). Sensitivity is defined as the percent of manually assembled pairs that can be identified by each tool versus all the manually assembled orthologous pairs (same for Figures 3a and 3b). In 3a, specificity is defined as the percent of manually assembled pairs that can be identified by each tool versus all the orthologous pairs identified by each tool if queried with either the Drosophila or the human genes from the test set. In 3b, specificity is defined as the percent of putative human-specific genes that do not have fly ortholog versus all the human specific genes from KOG list.