Table 3.
Disease phenotypes associated with Drosophila genes in the literature
| Mesh | # of fly genes | # of fly genes with human ortholog(s) | # of fly genes shared disease categories with their human ortholog | % fly genes with human ortholog(s) | % fly genes shared disease categories with their human ortholog |
|---|---|---|---|---|---|
| Neoplasms | 681 | 636 | 592 | 93% | 93% |
| Pathological Conditions, Signs and Symptoms | 2105 | 1713 | 1566 | 81% | 91% |
| Nervous System Diseases | 1179 | 1004 | 878 | 85% | 87% |
| Digestive System Diseases | 105 | 94 | 81 | 90% | 86% |
| Otorhinolaryngologic Diseases | 18 | 14 | 12 | 78% | 86% |
| Mental Disorders | 470 | 448 | 378 | 95% | 84% |
| Congenital, Hereditary, and Neonatal Diseases and Abnormalities | 1234 | 1100 | 900 | 89% | 82% |
| Cardiovascular Diseases | 139 | 126 | 103 | 91% | 82% |
| Stomatognathic Diseases | 20 | 20 | 16 | 100% | 80% |
| Skin and Connective Tissue Diseases | 148 | 123 | 98 | 83% | 80% |
| Immune System Diseases | 112 | 84 | 64 | 75% | 76% |
| Respiratory Tract Diseases | 8 | 8 | 6 | 100% | 75% |
| Disorders of Environmental Origin | 760 | 642 | 466 | 84% | 73% |
| Hemic and Lymphatic Diseases | 100 | 96 | 69 | 96% | 72% |
| Endocrine System Diseases | 163 | 144 | 103 | 88% | 72% |
| Nutritional and Metabolic Diseases | 577 | 452 | 310 | 78% | 69% |
| Female Urogenital Diseases and Pregnancy Complications | 558 | 413 | 276 | 74% | 67% |
| Virus Diseases | 38 | 32 | 21 | 84% | 66% |
| Musculoskeletal Diseases | 211 | 165 | 106 | 78% | 64% |
| Male Urogenital Diseases | 468 | 355 | 221 | 76% | 62% |
| Bacterial Infections and Mycoses | 325 | 233 | 99 | 72% | 42% |
| Eye Diseases | 699 | 590 | 221 | 84% | 37% |
| Parasitic Diseases | 229 | 187 | 21 | 82% | 11% |
| All Categories | 3557 | 2739 | 2283 | 77% | 83% |