Table 4.
Comparison of Drosophila disease genes identified from OMIM/GWAS and fly disease genes identified by literature mining
| Disease Category | Fly disease genes mapped from OMIM/GWAS | Fly disease genes from OMIM/GWAS that are studied in disease in literature | Fly disease genes from OMIM/GWAS with disease categories confirmed by literature | % of fly disease genes with disease categories confirmed by literature |
|---|---|---|---|---|
| Congenital, Hereditary, and Neonatal Diseases and Abnormalities | 2614 | 707 | 539 | 76% |
| Otorhinolaryngologic Diseases | 996 | 12 | 8 | 67% |
| Nervous System Diseases | 1901 | 669 | 431 | 64% |
| Musculoskeletal Diseases | 1433 | 88 | 56 | 64% |
| Cardiovascular Diseases | 1140 | 95 | 58 | 61% |
| Stomatognathic Diseases | 761 | 14 | 8 | 57% |
| Skin and Connective Tissue Diseases | 1349 | 72 | 36 | 50% |
| Digestive System Diseases | 1397 | 66 | 31 | 47% |
| Hemic and Lymphatic Diseases | 775 | 64 | 27 | 42% |
| Neoplasms | 673 | 382 | 145 | 38% |
| Male Urogenital Diseases | 1069 | 202 | 75 | 37% |
| Eye Diseases | 1356 | 334 | 120 | 36% |
| Respiratory Tract Diseases | 639 | 6 | 2 | 33% |
| Immune System Diseases | 523 | 56 | 18 | 32% |
| Female Urogenital Diseases and Pregnancy Complications | 1041 | 236 | 72 | 31% |
| Mental Disorders | 906 | 345 | 105 | 30% |
| Endocrine System Diseases | 627 | 94 | 27 | 29% |
| Nutritional and Metabolic Diseases | 896 | 255 | 71 | 28% |
| Parasitic Diseases | 28 | 122 | 2 | 2% |
| Pathological Conditions, Signs and Symptoms | 489 | 1074 | 143 | 13% |
| Bacterial Infections and Mycoses | 36 | 133 | 14 | 11% |
| Disorders of Environmental Origin | 1768 | 358 | 0% | |
| Virus Diseases | 48 | 24 | 0 | 0% |
| Substance-Related Disorders | 17 | 0 | 0% | |
| All Categories | 4282 | 1534 | 888 | 58% |