Table 10.
Live Virus Challenge of Monkeys after Tetravalent Immunization.
| Group | Animal ID |
PRNT50 for each serotype one month before challenge |
Challenge serotype assigned randomly |
Viremia (positive days) |
|---|---|---|---|---|
| 1 µg each tetravalent DEN-80E + 0.1 µg NS1 + ISCOMATRIX™ Adjuvant | AA37 | DEN1: 63 | ||
| DEN2: 139 | DEN4 | None | ||
| DEN3: 59 | ||||
| DEN4: 61 | ||||
| FTH | DEN1: 242 | |||
| DEN2: 309 | DEN2 | None | ||
| DEN3: 64 | ||||
| DEN4: 181 | ||||
| 5 µg each tetravalent DEN-80E + 0.5 µg NS1 + ISCOMATRIX™ Adjuvant | T206 | DEN1: 49 | ||
| DEN2: 39 | DEN4 | Days 4, 5, 6, 7 | ||
| DEN3: 192 | ||||
| DEN4: 14 | ||||
| AJ14 | DEN1: 51 | |||
| DEN2: 530 | DEN2 | None | ||
| DEN3: 270 | ||||
| DEN4: 148 | ||||
| Naive controls | B34Z | <10 for each serotype | DEN4 | Days 6, 7, 8, 9, 10 |
| B08Z | <10 for each serotype | DEN2 | Days 7, 8, 9, 10 | |