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. Author manuscript; available in PMC: 2012 Sep 23.
Published in final edited form as: Vaccine. 2011 Jul 21;29(42):7267–7275. doi: 10.1016/j.vaccine.2011.07.021

Table 4.

Duration of Immunity in Mice Immunized with DEN2-80E Formulated with Various Adjuvants

Vaccine
Formulation
Geometric Mean PRNT80 Titer
Month
1
Month
2
Month
3
Month
4
Month
5
Month
6
Post-
Boost
10 µg DEN2-80E ISCOMATRIX™ adjuvant* 6500 6062 5278 3703 4924 3732 12,996
25 µg DEN2-80E Ribi# 3177 4816 3249 2276 1784 906 6858
25 µg DEN2-80E MF75# 6063 6063 4756 2000 1207 2000 NT
25 µg DEN2-80E MF75+ThrMDP# 8000 5278 3031 3031 1320 3482 NT

NT – not tested, animals did not receive booster dose of vaccine.

*

Animals were immunized with 2 doses of vaccine administered at a 4 week interval.

#

Animals were immunized with 3 doses of vaccine at a 3 week interval. Dose 1 included 25 µg of DEN2-80E while the booster doses included 12.5 µg of DEN2-80E.

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