Table 4.
Duration of Immunity in Mice Immunized with DEN2-80E Formulated with Various Adjuvants
Vaccine Formulation |
Geometric Mean PRNT80 Titer | ||||||
---|---|---|---|---|---|---|---|
Month 1 |
Month 2 |
Month 3 |
Month 4 |
Month 5 |
Month 6 |
Post- Boost |
|
10 µg DEN2-80E ISCOMATRIX™ adjuvant* | 6500 | 6062 | 5278 | 3703 | 4924 | 3732 | 12,996 |
25 µg DEN2-80E Ribi# | 3177 | 4816 | 3249 | 2276 | 1784 | 906 | 6858 |
25 µg DEN2-80E MF75# | 6063 | 6063 | 4756 | 2000 | 1207 | 2000 | NT |
25 µg DEN2-80E MF75+ThrMDP# | 8000 | 5278 | 3031 | 3031 | 1320 | 3482 | NT |
NT – not tested, animals did not receive booster dose of vaccine.
Animals were immunized with 2 doses of vaccine administered at a 4 week interval.
Animals were immunized with 3 doses of vaccine at a 3 week interval. Dose 1 included 25 µg of DEN2-80E while the booster doses included 12.5 µg of DEN2-80E.