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. Author manuscript; available in PMC: 2012 Sep 23.
Published in final edited form as: Vaccine. 2011 Jul 21;29(42):7267–7275. doi: 10.1016/j.vaccine.2011.07.021

Table 5.

Homologous Virus Neutralizing Antibody Titers in Mice Immunized with Monovalent or Tetravalent DEN-80E Proteins Formulated with ISCOMATRIX™ Adjuvant

Immunogen Geometric Mean PRNT50 Titer
DENV1 DENV2 DENV3 DENV4
Monovalent* 2759 3031 381 174
Tetravalent+ 1589 2639 564 159
PBS <20 <20 <20 <20
*

4 groups of mice were immunized with 10 µg of each of the 4 monovalent 80E subunits. Each group was tested for homologous serotype virus neutralizing antibody titers.

+

1 group of mice was immunized with a tetravalent mixture containing 10 µg of each of the four 80E subunits. The group was tested individually for virus neutralizing antibody titers for each of the dengue serotypes.