Table 7.
Virus Neutralizing Antibody in Sera from Rhesus Monkeys Immunized with Recombinant DEN2-80E ISCOMATRIX™ Adjuvant Formulations
| Vaccine Formulation# |
Animal ID |
Virus Neutralizing Antibody Titers (PRNT50) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Day 0 |
Day 34 |
Day 49 |
Day 69 |
Day 97 |
Day 113 |
Day 132 |
Day 159 |
||
| 100 µg DEN2-80E + ISCOMATRIX™ adjuvant | G617 | <10 | 10 | 180 | 460 | 230 | 920 | 400 | >12,800 |
| B7487 | <10 | 110 | 480 | 480 | 600 | >640 | >640 | >12,800 | |
| 25 µg 80E + ISCOMATRIX™ adjuvant | F477 | <10 | <10 | 300 | 230 | 450 | 660 | 470 | >12,800 |
| I613 | <10 | 90 | 3000 | 1000 | 1100 | >1280 | >1280 | >12,800 | |
| 5 µg 80E + ISCOMATRIX™ adjuvant | I619 | <10 | 50 | 1600 | 590 | 1900 | >1280 | 1200 | >12,800 |
| H7J | <10 | 10 | 620 | 760 | 530 | >1280 | >640 | >12,800 | |
| 100 µg DEN2-80E + Aluminum hydroxide | F485 | <10 | 60 | 650 | 1200 | 250 | 770 | 600 | >12,800 |
| Placebo | N637 | NT* | NT | NT | NT | NT | NT | <10 | 860 |
| N670 | NT | NT | NT | NT | NT | NT | <10 | 1600 | |
| N816 | NT | NT | NT | NT | NT | NT | <10 | 990 | |
*
NT - not tested
#
Animals were immunized with 3 doses of vaccine administered by the subcutaneous route on days 0, 34, and 97.