Table 1.
Role of CB1 Receptor-Associated Proteins in Protein Trafficking and Signal Transduction
| CB1-Associated Protein | Site of CB1 interaction | Role in Protein Trafficking | Role in Signal Transduction | References |
|---|---|---|---|---|
| Gi1 | C-terminal side of Intracellular Loop 3 | -- | cAMP inhibition MAPK activation |
44,46,53,58 85–93 |
| Gi2 | N-terminal side of Intracellular Loop 3 | -- | cAMP inhibition MAPK activation |
44,46, 85–93 |
| Gi3 and Go | C-terminal Helix 8 | -- | cAMP inhibition Ca2+ channel inhibition MAPK activation |
44–56 60–69 85–93 |
| Gs | C-terminal side of Intracellular Loop 3 | -- | cAMP stimulation | 43,53,58,61, 76,77,80 |
| •-Arrestin | Mid-C-terminal tail; C-terminal distal 20 amino acids | Plasma membrane internalization | Desensitization of Kir3 Kinetics of MAPK | 133, 135, 137, 138–139 |
| AP-3 | Leu-Leu or Tyr signals | Late endosome budding to vesicles, or lysosomes | Gi- and ERK-associated | 130 |
| GASP1 | C-terminal Helix 8 | Targeting to lysosome | -- | 145–146 |
| CRIP1a and CRIP1b | Distal C-terminal tail | -- | Ca2+ channel inhibition | 150–152 |
| FAN | Mid-C-terminal tail | -- | Ceramide-mediated Raf1-MEK-ERK; stimulation of metabolic processes | 86–87, 162–163, 167–168 |