Table 1.

Alteration of NF-κB and IκB in cancer

Genes	Locus	Alteration	Tumor type	References
rela	11q13	amplification rearrangement splicing variant amino acid substitution overactivation	various types of lymphomas, including diffuse large B-cell lymphoma, primary mediastinal B-cell lymphoma and follicular large cell lymphoma; solid tumors such as squamous head and neck, breast and stomach adenocarcinoma B-cell non-Hodgkin's lymphoma and multiple myeloma non-small cell lung carcinoma multiple myeloma various types of cancers	[51,190-192]
relb	19q13.32	rearrangement	adult T-cell leukemia cell lines	[193]
c-rel	2p13-p12	amplification rearrangement overexpression	diffuse large B-cell lymphoma, primary mediastinal B-cell lymphoma, and follicular large cell lymphoma follicular lymphoma and diffuse large B-cell lymphoma follicular lymphoma, diffuse large cell lymphoma and non-small cell lung carcinoma	[51,190,194,195].
nf-kb1	4q24	rearrangement overexpression	acute lymphoblastic leukemia various cancers including non-small cell lung carcinoma, colon, prostate, breast and brain cancer	[51,196]
nf-kb2	10q24	rearrangement overexpression	cutaneous T-cell lymphoma, B-cell non-Hodgkin's lymphoma, B-cell chronic lymphocytic leukemia and multiple myeloma cutaneous T-cell lymphoma, breast and colon carcinoma	[51,196-199]
bcl3	19q13.1-q13.2	rearrangement overexpression	B-cell chronic lymphocytic leukemia and B-cell non-Hodgkin's lymphoma B-cell chronic lymphocytic leukemia and B-cell non-Hodgkin's lymphoma	[51,200,201]
ikbα	14q13	mutation	Hodgkin's disease	[51,85]
ikbε	6p11	mutation	Hodgkin's disease	[88]