Table 4.
NF-κB regulating microRNAs in cancer
| miRNA | Targets in NF-κB Signaling | Alteration in Cancer | Cancer linkage | Other Targets Linked to Cancer | References |
|---|---|---|---|---|---|
| NF-κB members | |||||
| miR-9 | NF-κB1 | epigenetically downregulated | gastric cancer and clear cell renal cell carcinoma | E-cadherin | [283-286] |
| miR-125b | Bcl-3 | downregulated | human liver cancer, melanoma, glioma, ovarian cancer, bladder cancer and breast cancer | LIN28B2; MUC1; E2F3; Endothelin-1; BAK1; BMF; CYP24; p53 | [165, 166, 170, 287-292] |
| NF-κB activators | |||||
| miR-15a, miR-16 | IKK1 | downregulated; deleted | chronic lymphocytic leukemia, multiple myeloma, lung squamous cell carcinoma and ovarian cancer | BMI-1 | [293-297] |
| miR-223 | IKK1 | downregulated | chronic lymphocytic leukemia and acute myeloid leukemia | E2F1 | [296, 298, 299] |
| miR-218 | IKK2 | downregulated | glioma, gastric cancer and lung squamous cell carcinoma | ROBO1; LASP1 | [300-304] |
| miR-199a | IKK2 | downregulated | breast cancer, melanoma and bladder cancer | MET; KRT7 | [163, 305-307] |
| miR-146a | IRAK1 TRAF6 | downregulated | breast cancer and pancreatic cancer | - | [308-310] |
| NF-κB inhibitors | |||||
| miR-181b-1 | CYLD | upregulated | acute lymphocytic leukemia | - | [140, 141] |
| miR-301a | NRF | upregulated | pancreatic tumor | - | [311] |