Table 4.
IC50 of Daunomycin (DNM) in the presence of Bcl-2 inhibitor ABT-737
| H69 (nM) | H69AR (nM) | |
|---|---|---|
| DNM alone | 86.64 | 1331.40 |
| DNM + 10 μM BSO + 1 μM VRP | 85.68 | 127.95 |
| DNM + 10 μM BSO + 1 μM VRP + 0.1μM ABT-737 | 21.33 | 131.27 |
| DNM + 10 μM BSO + 1 μM VRP + 1μM ABT-737 | 0.01 | 118.87 |
| DNM + 10 μM BSO + 1 μM VRP + 10μM ABT-737 | 0.00 | 134.90 |
| DNM + 10 μM BSO + 1 μM VRP + 0.1μM ABT-737 enantiomer | 81.72 | 101.95 |
| DNM + 10 μM BSO + 1 μM VRP + 1μM ABT-737 enantiomer | 85.51 | 111.48 |
| DNM + 10 μM BSO + 1 μM VRP + 10μM ABT-737 enantiomer | 53.90 | 77.15 |