Table 2.
Expression microarray comparing tumor versus normal epithelium and comparing tumor stroma versus normal stroma
| Immune Features – Tumor Cells vs Normal Epithelium | ||||
|---|---|---|---|---|
| Gene | Fold Change | OMIM | UniGene ID | Description |
| CXCL14 | 2.55 | 604186 NCBI | 483444 | Chemokine (C-X-C motif) ligand 14 |
| IL17RB | 2.08 | 605458 NCBI | 558512 | Homo sapiens interleukin 17 receptor B |
| PAWR | 1.52 | 601936 NCBI | 406074 | PRKC, apoptosis, WT1, regulator |
| IGSF4 | 1.38 | 605686 NCBI | 370510 | Immunoglobulin superfamily, member 4 |
| C7 | -1.21 | 217070 NCBI; 610102 NCBI | 78065 | Complement component 7 |
| FAS | -1.34 | 134637 NCBI; 601859 NCBI | 244139 | Fas (TNF receptor superfamily, member 6) |
| PRKCA | -1.39 | 176960 NCBI | 531704 | Protein kinase C, alpha |
| NKTR | -1.43 | 161565 NCBI | 529509 | Natural killer-tumor recognition sequence |
| ELF4 | -1.43 | n/a | 271940 | E74-like factor 4 (ets domain transcription factor) |
| HLA-DPA1 | -1.44 | 142880 NCBI | 347270 | Major histocompatibility complex, class II, DP alpha 1 |
| CXCR7 | -1.48 | 610376 NCBI | 471751 | Chemokine (C-X-C motif) receptor 7 |
| IFIT3 | -1.50 | n/a | 47338 | Interferon-induced protein with tetratricopeptide repeats 3 |
| ETS1 | -1.65 | 164720 NCBI | 369438 | v-ets erythroblastosis virus E26 oncogene homolog 1 |
| CD69 | -1.68 | 107273 NCBI | 208854 | CD69 antigen (p60, early T-cell activation antigen) |
| BCL2 | -1.70 | 151430 NCBI | 150749 | B-cell CLL/lymphoma 2 |
| CX3CL1 | -1.73 | 601880 NCBI | 531668 | Chemokine (C-X3-C motif) ligand 1 |
| IFI16 | -1.74 | 147586 NCBI | 380250 | Interferon, gamma-inducible protein 16 |
| CLU | -1.75 | 185430 NCBI | 436657 | Clusterin |
| IL6ST | -1.77 | 600694 NCBI | 532082 | Interleukin 6 signal transducer (gp130, oncostatin M receptor) |
| PTGER4 | -1.89 | 601586 NCBI | 199248 | Prostaglandin E receptor 4 (subtype EP4) |
| IL6ST | -1.91 | 600694 NCBI | 532082 | Interleukin 6 signal transducer (gp130) |
| CXCR4 | -1.98 | 162643 NCBI; 193670 NCBI | 421986 | Chemokine (C-X-C motif) receptor 4 |
| CEBPB | -2.11 | 189965 NCBI | 517106 | CCAAT/enhancer binding protein (Interleukin 6-dependent DNA-binding protein) |
| SOCS3 | -2.21 | 604176 NCBI | 527973 | Suppressor of cytokine signaling 3 |
| Immune Features – Tumor Stroma vs Normal Stroma | ||||
| Gene | Fold Change | OMIM | UniGene ID | Description |
| CXCL14 | 3.26 | 604186 NCBI | 483444 | Chemokine (C-X-C motif) ligand 14 |
| IGSF4D | 1.97 | 609938 NCBI | 164578 | Immunoglobulin superfamily, member 4D |
| CD24 | 1.78 | 126200 NCBI; 600074 NCBI | 632285 | CD24 antigen |
| TNFSF10 | 1.62 | 603598 NCBI | 478275 | Tumor necrosis factor (ligand) superfamily, member 10 |
| AZGP1 | 1.34 | 194460 NCBI | 546239 | Alpha-2-glycoprotein 1, zinc-binding |
| ARTS-1 | 1.20 | 606832 NCBI | 436186 | Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator |
| C3 | -1.14 | 120700 NCBI | 529053 | Complement component 3 |
| IGKC | -1.48 | 147200 NCBI | 552522 | Immunoglobulin kappa constant |
| HLA-C | -1.80 | 134580 NCBI; 147200 NCBI | 552522 | Major histocompatibility complex, class I, C |