Table 1. The Evolution of Sets of Protein–Ligand Complexes with Affinities.

database	year	no. complexes
Score1(12)	1994	54
Jain(13)	1996	34
VALIDATE(14)	1996	65
ChemScore(15)	1997	112
Score2(16)	1998	94
SCORE(17)	1998	181
PMF(18)	1999	225
BLEEP19,20	1999	90
DrugScore21,22	2000	83
LPDB(23)	2001	195
SMoG2001(24)	2002	119
HINT(25)	2002	53
X-Score(26)	2002	230
PLD(27)	2003	485
AffinDB(28)	2006	474
PDBbind – refined set	2007	1300
MOAD with affinities	2008	2948