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. 2011 Sep 5;4:16. doi: 10.1186/1756-8935-4-16

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Copyright ©2011 Stojic et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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H3K27me3/H3S28ph switch specifically influences the chromatin binding of the PRC2-Ezh2 complex but not PRC2-Ezh1. (A) Nuclear extracts from C2C12 myoblasts (growth medium (GM)) and myotubes (differentiation medium (DM), 48 h after differentiation induction) were incubated with peptides representing unmodified H3, K27me3-H3 or the double modification K27me3S28ph-H3. Binding of Ezh2, Suz12 and Eed was tested by immunoblot. (B) Nuclear extracts from C2C12 cells cultured in DM, 48 h after induction of differentiation, were incubated with the same peptides as those listed in (A) and the binding of Ezh2 and Ezh1 was tested by immunoblot.