Figure 7. The side effects of Free Tet and Tet-NPs.

a. The body weight change of the mice during therapy under different treatments. Body weight loss in this study is not an ideal parameter for the evaluation of wide effects in this study because every mouse received two different treatments. Nevertheless, the body weight of the Exp+NaHCO₃ group was much lower than in the Con+NaHCO₃ group while the differences of body weight between the Exp and Con group was not so obvious. b. Photos of the ulceration taken at the 7th day after administration. (A. Tet-NPs pH 6.8, B. Free Tet pH 6.8, C. Tet-NPs pH 7.4 and D. Free-Tet pH 7.4). Ulcerations were evaluated in details in Fig.S5.