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SDF-1a expression in the murine heart. There is reduced expression of mRNA for SDF-1a (A) in all regions of the murine heart following myocardial infarction. This occurs early, and remains suppressed for 28 days. There is no change in mRNA for its receptor CXCR4 (B). (C) Myocardial protein levels of SDF-1a are also reduced following MI. IZ = infarct zone; BZ = border zone of the infarct; RZ = remote zone. n = 3 for each region at each time-point.
