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. 2011 Sep 12;9:150. doi: 10.1186/1479-5876-9-150

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Copyright ©2011 Boyle et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MCP-1 release from the human heart. In humans, MCP-1 is constitutively released from hearts with normal coronary arteries. However, following myocardial infarction, myocardial release of MCP-1 is reduced. This is the opposite pattern suggested from the murine mRNA studies. Furthermore, MCP-1 release is suppressed in all stages of coronary artery disease, suggesting that coronary artery disease, rather than the tissue damage from MI, is responsible for the suppression of MCP-1 release. Transmyocardial gradient = coronary sinus level - coronary artery level; stable = stable coronary artery disease; UAP = unstable angina pectoris; MI = myocardial infarction.