Table 2.
In vivo Tumorigenicity of Side Population Isolated cells.
| RC-58T/hTERT/SA#4-D | |||
|---|---|---|---|
| Cell Types | Cell number | Incidence | Combined Estimated frequency |
| SPlow | 1,000 | 2/5 | 1/3,522 |
| (n = 18) | 5,000 | 2/4 | (1/1,661~1/7,466) |
| 10,000 | 6/6 | ||
| 50,000 | 3/3 | ||
| SPmid | 1,000 | 1/5 | 1/3,963 |
| (n = 15) | 5,000 | 4/4 | (1/1,762 ~1/8,914) |
| 10,000 | 3/4 | ||
| 50,000 | 2/2 | ||
| SPhi | 1,000 | 2/4 | 1/3,252 |
| (n = 14) | 5,000 | 4/4 | (1/1,356~1/7,805) |
| 10,000 | 2/3 | ||
| 50,000 | 2/2 | ||
| Non- | 1,000 | 1/4 | 1/25,952 |
| SP | 5,000 | 3/4 | (1/9,762~1/68,998) |
| (n = 14) | 10,000 | 1/3 | |
| 50,000 | 1/3 | ||
** Mice were killed at 15-17 weeks post-injection. All the cell doses, excluding negative mice, were used to calculate the limiting dilution experiments. 95% confidence interval was displayed in the bracket. Combined Frequency for SP = 1/3,574 (1/2,243~1/5,695)