Table 10.
Summary of DHA pharmacokinetic results following rectal AS administration.
| Ref. | Subjects & Regimen | Cmax (ng/mL) | Tmax (hours) | Clearance (L/kg/hr) | Volume (L/kg) | Half-life (hours) | AUC (ng*hr/mL) |
|---|---|---|---|---|---|---|---|
| [49] Sirivichay et al, 2007 |
16 paediatric patients with uncomplicated falciparum malaria 10 mg/kg (n = 7) or 20 mg/kg (n = 9) AS as rectal suppositories |
898; 1535†a | 1.5; 2.0a | 1.3; 1.8a | 2403; 5633†a | ||
| [50] Halpaap et al, 1998 |
12 paediatric patients with uncomplicated falciparum malaria 50 mg AS as rectal suppository [0.86 - 2.55 mg/kg AS] |
180† | 1.13 | ||||
| [42] Awad et al, 2004 |
12 healthy Sudanese adults 200 mg AS as rectal suppository |
219.1† | 1.95 | 1.21 | 1185.17 | ||
| [30] Navaratnam et al, 1998 |
12 healthy Malaysian adults 200 mg AS as rectal suppository |
385.6† | 1.80 | AUC0-t 965 |
|||
| Krishna et al, 2001 [15] |
34 Ghanaian children (8 months - 7 years) with moderate falciparum malaria Group 1: AS 10 mg/kg as rectal suppository, IV AS 2.4 mg/kg 12 hr later Group 2: AS 20 mg/kg AS as rectal suppository, IV AS 2.4 mg/kg 12 hr later Group 3: 2.4 mg/kg IV AS, 20 mg/kg AS as rectal suppository 12 hr later |
Group 1: 682†a Group 2 & 3: 881†a |
Group 1: 1.7a Tlag: 0.63a Group 2 & 3: 1.8a Tlag: 0.37a |
Group 1: 2.6 Group 2 & 3: 3.9 |
Group 1: 4.4a Group 2 & 3: 5.9a |
Group 1: 0.79a Group 2 & 3: 0.85a |
Group 1: 2787 †a Group 2 & 3: 3753†a |
Estimates from PopPK studies are described in the text. Values given as mean unless otherwise specified
†Units converted to uniform scale a. Median