Table 2.
Summary of DHA pharmacokinetic results following IV AS administration.
| Ref. | Subjects & Regimen | Cmax (ng/mL) | Tmax (min) | Clearance (L/kg/hr) | Volume (L/kg) | Half-life (min) | AUC (ng*hr/mL) |
|---|---|---|---|---|---|---|---|
| [7] Batty, Le et al, 1998 |
12 Vietnamese adults with vivax malaria 120 mg IV AS over 2 min |
2192†a | 8a | 1.10 | 0.92 | 36.7 | 1845† |
| [9] Binh et al, 2001 |
17 healthy Vietnamese volunteers; subjects randomized into two groups, both receiving: 120 mg IV AS over 2 min |
1507; 1678† | 9; 16 | 53; 47 | |||
| [10] Ilett et al, 2002 |
23 Vietnamese adults with uncomplicated falciparum malaria; subjects randomized into two groups, both receiving: 120 mg IV AS over 2 min |
2758; 2730†a | 7; 9a | 0.64; 0.48 | 0.8; 0.55 | 59; 50 | 2872; 3298† |
| [11] Li et al, 2009 |
30 healthy volunteers 0.5, 1, 2, 4, or 8 mg/kg IV AS over 2 min |
428; 802; 1286; 3148; 4744 | 9.6; 15; 9.6; 7.2; 24† | 1.3; 0.98; 1.1; 0.86; 0.82† | Vss: 1.734; 2.201; 1.860; 1.701; 2.403† | 57.6; 92.4; 69.0; 82.2; 128.4† | 385; 1082; 1850; 4886; 10410 |
| [12] Nealon et al, 2002 |
28 paediatric Gabonese patients with severe malaria randomized into two groups Group 1: 2.4 mg/kg IV AS Group 2: 1.2 mg/kg IV AS |
Group 1: 3011†a Group 2: 1584†a |
Group 1: 0.5a Group 2: 1.4a |
Group 1: 2.16†a Group 2: 1.08†a |
Group 1 Vss: 0.75a Group 2 Vss: 0.77a |
Group 1: 20.7a Group 2: 32.0a |
Group 1: 923†a Group 2: 737†a |
| [13] Newton et al, 2006 |
17 adults with severe falciparum malaria in Thailand 2.4 mg/kg IV AS over 2 min [2.1 (1.4 - 2.8 mg/kg)] |
605†a | Tmax reached by 15 min | 5.6a | Vss: 1.9a | 20.4†a | 418†a |
| [8] Batty. Thu et al, 1998 |
26 adult uncomplicated falciparum malaria patients in Vietnam 120 mg IV AS over 2 min |
2648†a | 9.0a | 0.75a | 0.76 | 40.2 | 2377† |
| [14] Davis et al, 2001 |
30 parasitaemic adults with falciparum malaria Group 1: 12 with complications Group 2: 8 without complications Group 1 & 2: 120 mg IV AS over 2 min Group 3: 10 with moderately severe complications (240 mg IV AS infused over 4 hours; samples taken after infusion discontinued) |
Group 1: 2417† Group 2: 2531† Group 3: 910 † |
Group 1: 10.4 Group 2: 9.9 Group 3: 240 (end of infusion) |
Group 1: 1.09 Group 2: 0.73 Group 3: 0.73 |
Group 1: 0.77 Group 2: 1.01 Group 3: 0.78 |
Group 1: 40.0 Group 2: 64.1 Group 3: 46.2 |
Group 1: 2078† Group 2: 2559† Group 3: 5573† |
| Krishna et al, 2001 [15] |
34 Ghanaian children (8 months - 7 years) with moderate falciparum malaria Group 1 & 2: AS rectal suppository, IV AS 2.4 mg/kg 12 hr later Group 3: 2.4 mg/kg IV AS, AS rectal suppository 12 hr later |
Groups 1 & 2: 1280†a Group 3: 1592 †a |
Groups 1 & 2: 12†a Group 3: 12† |
Groups 1 & 2: 1.5a Group 3: 1.0a |
Groups 1 & 2: 0.6a Group 3: 0.9a |
Groups 1 & 2: 18†a Group 3: 31.8†a |
Groups 1 & 2: 1166†a Group 3: 1706†a |
Values given as mean unless otherwise specified.
†Units converted to uniform scale a. Median