Table 4.
Summary of DHA pharmacokinetic results following IM AS administration.
| Ref. | Subjects & Regimen | Cmax (ng/mL) | Tmax (min) | Clearance (L/kg/hr) | Volume (L/kg) | Half-life (min) | AUC (ng*hr/mL) |
|---|---|---|---|---|---|---|---|
| [10] Ilett et al, 2002 |
11 Vietnamese adults with uncomplicated falciparum malaria 120 mg AS administered by intramuscular injection |
1166†a | 45a | 0.73 | 1.1 | 64 | 2474† F: 88% |
| [21] Hien et al, 2004 |
9 Vietnamese adults with severe falciparum malaria 2.4 mg/kg AS administered by intramuscular injection |
870†a | 35a | 1.18a | 1.79a | 52.7a | 1496†a |
| [12] Nealon et al, 2002 |
28 paediatric Gabonese patients with severe malaria randomized into two groups Group 1: 2.4 mg/kg IV AS, followed by 1.2 mg/kg IM AS 12 hours later Group 2: 2.4 mg/kg IM AS, followed by 1.2 mg/kg IV AS 12 hours later |
Group 1: 341a Group 2: 626a |
Group 1: 25.9a Group 2: 40.5a |
Group 1: 2.16†a Group 2: 1.5†a |
Group 1: Vc/F: 1.2a Vss/F: 1.32a Group 2: Vc/F: 1.2a Vss/F: 1.28a |
Group 1: 31.9a Group 2: 40.2a |
Group 1: 396†a Group 2: 1123†a Combined group F: 86.37%a |
Values given as mean unless otherwise specified.
†Units converted to uniform scale a. Median