Table 5.
Artesunate Tmax values obtained following oral artesunate administration.
| Ref. | Subjects | Regimen | Tmax (hours) |
|---|---|---|---|
| [23] | 15 healthy Cambodian male adults | 4 mg/kg AS once with mefloquine | 0.75a |
| [6] | 8 healthy adults in Australia | 150 mg AS once | 0.65 (n = 6)a |
| [24] | 20 healthy adult males in Australia | 200 mg/day × 3 days alone (Period 1); repeated with mefloquine after washout (Period 2) | Period 1/Day 1: 0.6b Period 1/Day 3: 0.6b Period 2/Day1: 0.5b Period 2/Day 3: 0.6b |
| [25] | 6 healthy adults in Geneva | 200 mg AS once | 0.25 (5/6 subjects) 0.5 (1/6 subjects) |
| [26] | 23 healthy Malaysian adults | 200 mg AS once with amodiaquine as fixed or non-fixed product | Fixed:0.26 Non-fixed:0.53 |
| [27] | 13 healthy adults in Africa | Mean dose: 4.26 mg/kg with (ACT) or without (AS only) amodiaquine as single dose | AS only: 0.62 ACT: 0.86 |
| [28] | 8 healthy male Thai adults | 300 mg AS (Guilin or Arenco formulation) | Guilin: 0.25a Arenco: 0.31a |
| [29] | 10 healthy male Vietnamese adults | 200 mg AS once daily × 5 days | Day 1: 0.8a Day 5: 0.8a |
| [30] | 12 healthy male Malaysian adults | 200 mg AS once | 0.66 ± 0.34 |
| [31] | 11 male Thai adults with uncomplicated falciparum malaria | 200 mg AS once, followed by 100 mg 12 hours later, then 100 mg once daily for another 4 days | Acute: 0.5a Convalescence:1.0a |
| [32] | 43 adults with uncomplicated falciparum malaria in Thailand | AS+mefloquine as fixed (200 mg AS) or nonfixed (4 mg/kg AS) combination | Fixed:0.833 (n = 19) Nonfixed:0.925 (n = 23) |
| [33] | 13 male and female adult patients in the DRC with acute uncomplicated falciparum malaria | 200 mg AS once daily × 3 days with amodiaquine | 1.4 (n = 10) |
| [34] | 86 acute uncomplicated falciparum malaria patients from Malawi and Gambia | 1, 2, or 4 mg/kg AS with chlorproguanil and dapsone once daily × 3 days | 1 mg/kg: 1.08a 2 mg/kg: 0.55a 4 mg/kg: 1.03a |
| [35] | 6 male Thai adults with uncomplicated falciparum malaria and 6 healthy male adults | 100 mg AS once | Healthy: 0.71 Patients: not determined |
| [36] | 57 children (2-14 years) with uncomplicated falciparum malaria in Gabon | AS dose (mg/kg/day) with pyronaridine Group A:2.1(1.4-2.4) Group B:3.3(2.4 - 3.9) Group C:4.8(3.0 - 6.1) Group D: 3.8(3.0-4.3) |
Group A:0.6 Group B:0.7 Group C:1.0 Group D:0.5 |
| [37] | 40 children and adults with uncomplicated falciparum malaria in Pailin, Cambodia and 40 adults with uncomplicated falciparum malaria in Wang Pha, Thailand | At each site: Group 1: AS monotherapy: 2 mg/kg/day × 7 days Group 2: AS 4 mg/kg/day × 3 days + mefloquine |
Thailand: Group 1: 0.38a Group 2: 0.50a Cambodia: Group 1:0.50a Group 2: 1.00a |
Values given as mean unless otherwise specified.
a. Median b. Geometric mean