Table 6.

Artesunate half-life values following oral artesunate administration.

Ref.	Subjects	Artesunate regimen	Artesunate half-life (hours)
[29]	10 healthy male Vietnamese adults	200 mg once daily × 5 days	Day 1: 0.43a Day 5: 0.50a
[30]	12 healthy male Malaysian adults	200 mg single dose	0.49
[28]	8 healthy male Thai adults	300 mg AS (Guilin or Arenco formulation)	Guilin:0.53 Arenco:0.57
[26]	23 healthy Malaysian adults	200 mg AS + amodiaquine as fixed or non-fixed product	Fixed:0.63 Non-fixed:0.76
[34]	86 acute uncomplicated falciparum malaria patients from Malawi and Gambia	1, 2, or 4 mg/kg AS + chlorproguanil and dapsone once daily × 3 days	1 mg/kg: 0.515b 2 mg/kg: 0.478b 4 mg/kg: 0.467b
[31]	11 male Thai adults with uncomplicated falciparum malaria	200 mg AS once, followed by 100 mg 12 hours later, then 100 mg once daily × 4 days	Acute: 0.36a Convalescence: 0.54a
[35]	6 male Thai adults with uncomplicated falciparum malaria and 6 healthy male adults	100 mg AS once	Healthy: 0.41 Patients: not determined
[36]	57 children (2-14 years) with uncomplicated falciparum malaria in Gabon	AS dose (mg/kg) with pyronaridine Group A:2.1(1.4-2.4) Group B:3.3(2.4 - 3.9) Group C:4.8(3.0 - 6.1) Group D: 3.8(3.0-4.3)	Group A: 0.8 (n = 12) Group B:1.1 (n = 12) Group C:0.5 (n = 10) Group D:1.2 (n = 13)
[37]	40 children and adults with uncomplicated falciparum malaria in Pailin, Cambodia and 40 adults with uncomplicated falciparum malaria in Wang Pha, Thailand	At each site: Group 1: AS monotherapy: 2 mg/kg/day × 7 days Group 2: AS 4 mg/kg/day × 3 days + mefloquine	Thailand: Group 1: 0.37a Group 2: 0.58a Cambodia: Group 1: 0.29a Group 2: 0.29a

Value given as mean unless otherwise specified.

a. Median b. Geometric mean