Table 8.

DHA half-life values obtained following artesunate administration.

Ref.	Subjects	Artesunate regimen	DHA half-life (hours)
[29]	10 healthy male Vietnamese adults	200 mg once daily × 5 days	0.87 (from pooled data)
[30]	12 healthy male Malaysian adults	200 mg single dose	0.49
[40]	20 male and female healthy Thai adults	4 mg/kg once	0.74a
[27]	13 healthy adults in Africa	Mean dose: 4.26 mg/kg with (ACT) or without (AS only) amodiaquine single dose	AS only:1.46 ACT: 3.08
[28]	8 healthy male Thai adults	300 mg AS (Guilin or Arenco formulation)	Guilin: 1.77 Arenco:1.73
[41]	10 healthy Vietnamese males	100 mg AS once	Half-life: 0.55b
[25]	6 healthy adults in Geneva	200 mg AS once	0.65
[26]	23 healthy Malaysian adults	200 mg once with amodiaquine as fixed or non-fixed product	Fixed:1.68 Non-fixed:1.42
[24]	20 healthy adult males in Australia	200 mg/day × 3 days alone (Period 1); repeated with mefloquine after washout (Period 2)	Period 1/Day 1: 1.14 Period 1/Day 3: 1.14 Period 2/Day 1: 1.02 Period 2/Day 3: 1.09
[23]	15 healthy Cambodian male adults	4 mg/kg once with mefloquine	1.30b
[42]	12 healthy adults	200 mg once	0.68
[34]	86 acute uncomplicated falciparum malaria patients from Malawi and Gambia	1, 2, or 4 mg/kg AS with chlorproguanil and dapsone once daily × 3 days	1 mg/kg: 0.779b 2 mg/kg: 0.917b 4 mg/kg: 1.09b
[7]	12 Vietnamese adult male vivax malaria patients	100 mg single dose	0.67 (n = 11)
[8]	26 Vietnamese adult patients with uncomplicated falciparum malaria	100 mg single dose	0.66 (n = 16)
[39]	21 children (5 - 13 years) with uncomplicated malaria in Uganda	4 mg/kg once daily with amodiaquine × 3 days	1.3a
[38]	24 children with uncomplicated falciparum malaria in Gabon	4 mg/kg once daily for 3 days in one of two formulations (blister pack and fixed dose) of AS/mefloquine	Fixed dose: 0.9(n = 9)a Blister pack: 1.0 (n = 11)a
[32]	43 adults with uncomplicated falciparum malaria in Thailand	200 mg/day for fixed dose AS-mefloquine tablet or 4 mg/kg/day as nonfixed AS-mefloquine	Fixed: 1.1 (n = 14) Nonfixed: 0.8 (n = 18)
[31]	11 male Thai adults with uncomplicated falciparum malaria	200 mg AS once, followed by 100 mg 12 hours later, then 100 mg once daily × 4 days	Acute: 0.64a Convalescence: 0.66a
[43]	24 pregnant Karen women in the 2nd and 3rd trimesters with uncomplicated falciparum malaria	4 mg/kg once daily × 3 days with atovaquone plus proguanil	Half-life: 1.0 (n = 13)a PopPK half-life estimate: 1.81 hr
[35]	6 male Thai adults with uncomplicated falciparum malaria and 6 healthy male adults	100 mg AS once	Healthy: 0.85 Patients: 1.06
[9]	8 Vietnamese adults with uncomplicated falciparum malaria and 10 healthy Vietnamese adults	150 mg once	Healthy: 0.77 Patients: 0.88
[53]	26 2nd and 3rd trimester pregnant women with asymptomatic falciparum parasitaemia, the same women postpartum, and 25 non-pregnant asymptomatic, parasitaemic controls	200 mg once	Pregnant: 1.28a Postpartum:1.63a Controls: 1.41a
[36]	57 children (2-14 years) with uncomplicated falciparum malaria in Gabon	AS dose (mg/kg) Group A:2.1(1.4-2.4) Group B:3.3(2.4 - 3.9) Group C:4.8(3.0 - 6.1) Group D: 3.8(3.0-4.3) Administered with pyronaridine	Group A:1.0 Group B: 0.9 Group C: 1.2 Group D:1.2
[37]	40 children and adults with uncomplicated falciparum malaria in Pailin, Cambodia and 40 adults with uncomplicated falciparum malaria in Wang Pha, Thailand	At each site: Group 1: AS monotherapy: 2 mg/kg/day × 7 days Group 2: AS 4 mg/kg/day × 3 days + mefloquine	Thailand: Group 1: 0.71a Group 2: 0.85a Cambodia: Group 1: 0.84a Group 2: 0.77a

Estimates from PopPK studies are described in the text. Values given as mean unless otherwise specified.

a. Median b. Geometric mean