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. 2011 Sep 26;6(9):e25365. doi: 10.1371/journal.pone.0025365

Figure 4. Localisation of EGF repeat binding site in CePOFUT1.

Figure 4

(A). Electrostatic surface representation of CePOFUT1 and HsEGF12 (PDB code 2VJ3). CePOFUT1 has an overall positive charge in the sugar and acceptor binding site while HsEGF12 is negatively charged around Thr466 [56]. GDP-fucose is shown as sticks with green carbon atoms while Thr466 is indicated by an arrow. (B). Docking of HsEFG12 into CePOFUT1. CePOFUT1 is represented as a surface model colored by sequence conservation, while HsEGF12 is shown either as ribbon representation on the left (β-strands are in blue and the three disulphide bridges are highlighted in yellow) or as a surface model (in orange) on the right. GDP-fucose and Thr466 are shown as sticks with green carbon atoms.