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. 2011 Sep 26;6(9):e25433. doi: 10.1371/journal.pone.0025433

Figure 8. Effect of cisplatin-loaded nanoparticles on athymic mice.

Figure 8

(A) Effect of free cisplatin (3 mg/kg) and cisplatin-loaded nanoparticles (NPs-cp, 3 mg/kg on the basis of cisplatin) on tumor growth in athymic mice bearing with IGROV1-CP cell xenografts. The mice were administered with prepared formulations at 4-day intervals in the total treatment period of 21 days. Saline solution was used as the control group, and the effect of blank nanoparticles (blank NPs) was also confirmed. The data were presented as Mean ± SD (n = 8 at the beginning of the experiment). (B) Survival rate of tumor-bearing athymic mice treated with cisplatin (3 mg/kg), NPs-cp (3 mg/kg on the basis of cisplatin), blank NPs and saline (control). (C) Body weight change as the treatment time of IGROV1-CP tumor-bearing mice. Bars indicated standard deviations.