Table 1.

Approved indications for GH use in the USA and Europe

Indication	Year of FDA approval
GH-deficiency states
Childhood growth-hormone deficiency	1985 (E)
Adult growth-hormone deficiency	1996 (E)
Pubertal dosing	2000
Non-GH-deficiency states
Chronic kidney disease	1993 (E)
Turner syndrome	1996 (E)
Aids wasting	1996
Prader–Willi syndrome	2000 (E)
Small for gestational age	2001 (E)
Idiopathic short stature	2003
Small bowel syndrome	2004
SHOX deletion	2006 (E)
Noonan syndrome	2007

Abbreviations: E, Europe; FDA, US Food and Drug Administration; GH, growth hormone.