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. 2011 Jun 20;589(Pt 17):4189–4207. doi: 10.1113/jphysiol.2011.211367

Figure 2. STN single stimulation induced excitatory and inhibitory evoked responses in SNr neurons.

Figure 2

A and B, characterization of inward and outward currents evoked by STN single stimulation. Inward currents show in A and outward currents in B, correspond to whole-cell recordings in the same neurons in C and D, respectively. The black line represents the average of 35 inward currents (A) and 30 consecutive outward currents (B) raw traces (grey lines). Top histograms: representative histograms of latency and amplitude distributions of 35 inward currents (A) and 30 outward currents (B). Bottom histograms: latency distribution of 390 inward currents recorded in 26 SNr neurons (15 measurements per neuron) (A) and 285 outward currents recorded in 19 neurons (15 measurements per neuron) (B). Boxes and bars represent SD of latency of 26 (A) and 19 neurons (B); bars represent minimal and maximal values; the median value is represented by the horizontal line in each box. SD of latency (<1 ms) indicates that inward and outward currents were monosynaptic. C and D, whole-cell recordings of PSPs and spontaneous frequencies (C: EPSP; D: IPSP). E and F, a STN single stimulation induced either a significant increase (E) or decrease (F) of the spontaneous firing rate (cell-attached recordings) in two representative SNr neurons (20 trials per neuron). The vertical dashed line indicates the STN single stimulation. ISIn: number of the interspike interval related to the ISI0 (at STN single stimulation).