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A, based on our estimates for the number of docked vesicles as well as the number of VGCCs expressed in a single endbulb terminal, we propose that an average number of 7–8 VGCCs is associated with each docked vesicle at endbulb AZs. B, upon AP arrival, 3–4 VGCCs are opened at the peak of the AP-induced Ca2+ current.
