Table 2.
Statistical analysis summary of CGI-S, parent and teacher FBB-ADHD and DAYAS scores
| Scales | N | Assessment point | Main effect MANOVA and effect size | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Visit 1 | Visit 2 | Visit 3 | F* | Cohen’s d (Visit 1–Visit 3) | |||||
| Mean | SD | Mean | SD | Mean | SD | ||||
| Clinical rating | |||||||||
| Global impression (CGI-S) | 634 | 2.02 | 0.67 | 1.43 | 0.69 | 1.07 | 0.65 | 447.5 | 1.17 |
| Parent ratings (FBB-ADHD) | |||||||||
| Inattention | 701 | 1.87 | 0.63 | 1.35 | 0.60 | 1.21 | 0.58 | 334.5 | 0.95 |
| Hyperactivity/impulsivity | 699 | 1.43 | 0.79 | 1.02 | 0.70 | 0.86 | 0.65 | 256.4 | 0.85 |
| ADHD total | 699 | 1.63 | 0.62 | 1.17 | 0.59 | 1.02 | 0.56 | 356.2 | 1.00 |
| Functional impairment | 698 | 1.83 | 0.73 | 1.38 | 0.73 | 1.15 | 0.71 | 238.2 | 0.82 |
| Attention-reflexivity | 699 | 0.88 | 0.62 | 1.14 | 0.64 | 1.22 | 0.65 | 87.8 | 0.49 |
| Teacher ratings (FBB-ADHD) | |||||||||
| Inattention | 522 | 1.60 | 0.73 | 1.27 | 0.67 | 1.11 | 0.66 | 123.5 | 0.69 |
| Hyperactivity/impulsivity | 521 | 1.07 | 0.85 | 0.81 | 0.73 | 0.68 | 0.66 | 73.3 | 0.53 |
| ADHD total | 520 | 1.31 | 0.71 | 1.02 | 0.63 | 0.88 | 0.59 | 110.9 | 0.65 |
| Functional impairment | 519 | 1.50 | 0.89 | 1.17 | 0.80 | 0.98 | 0.76 | 98.8 | 0.62 |
| Attention-reflexivity | 511 | 0.98 | 0.63 | 1.16 | 0.64 | 1.24 | 0.63 | 44.5 | 0.41 |
| Day profile-parent (DAYAS-P) | |||||||||
| Total score | |||||||||
| Morning before school | 682 | 1.37 | 0.77 | 1.08 | 0.73 | 1.02 | 0.72 | 96.1 | 0.51 |
| Afternoon | 668 | 1.51 | 0.68 | 1.09 | 0.63 | 0.94 | 0.61 | 209.4 | 0.78 |
| Late afternoon | 685 | 1.61 | 0.68 | 1.30 | 0.64 | 1.20 | 0.64 | 125.1 | 0.59 |
| Evening | 683 | 1.48 | 0.74 | 1.29 | 0.72 | 1.20 | 0.72 | 56.4 | 0.40 |
| ADHD symptoms | |||||||||
| Morning before school | 681 | 1.38 | 0.81 | 1.09 | 0.78 | 1.02 | 0.78 | 80.3 | 0.47 |
| Afternoon | 667 | 1.55 | 0.71 | 1.11 | 0.66 | 0.94 | 0.64 | 217.0 | 0.77 |
| Late afternoon | 682 | 1.65 | 0.70 | 1.35 | 0.65 | 1.25 | 0.67 | 103.3 | 0.54 |
| Evening | 679 | 1.50 | 0.77 | 1.32 | 0.76 | 1.23 | 0.76 | 41.7 | 0.35 |
| ODD symptoms | |||||||||
| Morning before school | 678 | 1.28 | 0.88 | 1.01 | 0.79 | 0.95 | 0.79 | 59.8 | 0.40 |
| Afternoon | 660 | 1.35 | 0.82 | 1.01 | 0.73 | 0.89 | 0.71 | 102.5 | 0.55 |
| Late afternoon | 679 | 1.49 | 0.83 | 1.20 | 0.77 | 1.11 | 0.76 | 84.3 | 0.48 |
| Evening | 674 | 1.41 | 0.87 | 1.20 | 0.83 | 1.13 | 0.79 | 45.5 | 0.36 |
| Day profile-teacher (DAYAS-T) | |||||||||
| Total score | |||||||||
| Morning first half | 515 | 1.07 | 0.74 | 0.84 | 0.64 | 0.73 | 0.60 | 57.3 | 0.47 |
| Morning second half | 494 | 1.42 | 0.81 | 1.10 | 0.72 | 0.96 | 0.69 | 95.3 | 0.61 |
| ADHD symptoms | |||||||||
| Morning first half | 515 | 1.16 | 0.78 | 0.91 | 0.67 | 0.78 | 0.63 | 63.2 | 0.50 |
| Morning second half | 494 | 1.60 | 0.85 | 1.21 | 0.76 | 1.06 | 0.72 | 111.6 | 0.66 |
| ODD symptoms | |||||||||
| Morning first half | 514 | 0.83 | 0.81 | 0.67 | 0.69 | 0.60 | 0.66 | 24.4 | 0.30 |
| Morning second half | 492 | 1.09 | 0.91 | 0.87 | 0.81 | 0.74 | 0.76 | 42.6 | 0.41 |
ADHD attention deficit hyperactivity disorder, CGI-S clinical global impression severity, DAYAS day profile of ADHD assessment, DAYAS-P/T DAYAS-parent/teacher, FBB-ADHD Fremdbeurteilungsbogen für Aufmerksamkeitsdefizit-Hyperaktivitätsstörung, M mean, MANOVA multivariate analysis of variance, ODD oppositional defiant disorder, SD standard deviation
* All effects are statistically significant at P < 0.001