Table 2.
Screening performance of the two esophagogastroduodenoscopies in subjects with or without Helicobacter pylori infection (mean ± SD) n (%)
| Total subjects (H. pylori analyzed) | H. pylori |
||
| Positive | Negative | ||
| Screened by transnasal EGD | |||
| Screened subjects | 1280 | 510 | 770 |
| Age (yr) | 53.4 ± 15.4 | 56.8 ± 13.6c | 50.2 ± 14.3 |
| Males | 623 (48.7)a | 268 (52.5)a | 355 (46.1)a |
| Smokers | 247 (19.3) | 118 (23.1)c | 129 (16.7)a |
| Subjects with gastric neoplasia/DR | 21/0.0164 | 16/0.0314c | 5/0.00649 |
| Location of neoplasia (U/M/L) | 7/6/8 | 4/6/6 | 3/0/2 |
| Adenoma cases/DR | 3/0.0023 | 3/0.00589 | 0/0 |
| Size of adenoma (mm) | 9.7 ± 4.0 | 9.7 ± 4.0 | 0 |
| Cancer cases/DR | 18/0.0141 | 13/0.0255c | 5/0.00649 |
| Size of cancer (mm) | 31.2 ± 19.5 | 25.5 ± 13.3 | 46.0 ± 28.2 |
| Morphological cancer type (I-IIa/IIb/IIc-III/Ad) | 6/1/4/7 | 5/0/4/4 | 1/1/0/3 |
| With intestinal-type cancer | 16 (88.9) | 12 (92.3) | 4 (80) |
| Depth of invasion (m/sm/pm-) | 5/6/7 | 4/5/4 | 1/1/3 |
| With early cancer | 12 (66.7) | 10 (76.9) | 2 (40) |
| Screened by transoral EGD | |||
| Screened subjects | 1707 | 692 | 1015 |
| Age (yr) | 53.5 ± 15.4 | 56.3 ± 14.7c | 51.8 ± 14.8 |
| Males | 655 (38.4) | 298 (43.1) | 357 (35.2) |
| Smokers | 354 (20.7) | 141 (20.3) | 213 (21.0) |
| Subjects with gastric neoplasia/DR | 33/0.0193 | 26/0.0376c | 6/0.00591 |
| Location of neoplasia (U/M/L) | 12/8/12 | 10/8/9 | 2/0/3 |
| Adenoma cases/DR | 9/0.0052 | 5/0.00722 | 4/0.00394 |
| Size of adenoma (mm) | 10.8 ± 7.9 | 13 ± 11.5 | 10 ± 4.08 |
| Cancer cases/DR | 23/0.0135 | 21/0.0303c | 2/0.00197 |
| Size of cancer (mm) | 22.3 ± 12.8 | 23.2 ± 13.4 | 20 ± 0 |
| Morphological cancer type (I-IIa/IIb/IIc-III/Ad) | 6/0/12/5 | 6/0/10/5 | 0/0/2/0 |
| With intestinal-type cancer | 15 (65.2) | 14 (66.7) | 1 (50) |
| Depth of invasion (m/sm/pm-) | 15/3/5 | 13/3/5 | 2/0/0 |
| With early cancer | 18 (78.3) | 14 (76.2) | 2 (100) |
a
P < 0.05 vs transoral,
c
P < 0.05 vs Helicobacter pylori (H. pylori)-negative. DR: Detection rate; U: Upper third of the stomach; M: Middle third of the stomach; L: Lower third of the stomach; EGD: Esophagogastroduodenoscopy.