Table 4.
Screening performance of the two esophagogastroduodenoscopies according to the stages of Helicobacter pylori-related chronic gastritis (mean ± SD) n (%)
| Group A | Group B | Group C | Group D | Total subjects (H. pylori analyzed) | |
| Screened by transnasal EGD | |||||
| Screened subjects | 572 | 189 | 321 | 198 | 1280 |
| Age (yr) | 45.3 ± 13.8 | 49.2 ± 14.6c | 59.8 ± 12.1c | 63.4 ± 12.8c | 53.4 ± 15.4 |
| Males | 257 (44.9)a | 74 (39.3) | 194 (60.2)a | 98 (49.4) | 623 (48.7)a |
| Smokers | 89 (15.6)a | 43 (22.8)a | 75 (23.3) | 40 (20.2) | 247 (19.2) |
| Subjects with gastric neoplasia/DR | 0/0 | 1/0.0053ac | 15/0.0466c | 5/0.0253 | 21/0.0164 |
| Location of neoplasia (U/M/L) | 0 | 0/1/0 | 4/5/6 | 3/0/2 | 7/6/8 |
| Adenoma cases/DR | 0/0 | 0/0 | 3/0.0093 | 0/0 | 3/0.0023 |
| Size of adenoma (mm) | 0 | 0 | 9.7 ± 4.0 | 0 | 9.7 ± 4.0 |
| Cancer cases/DR | 0/0 | 1/0.00532 | 12/0.0373 | 5/0.0253 | 18/0.0141 |
| Size of cancer (mm) | 0 | 5 ± 0 | 27.3 ± 12.3 | 46.0 ± 28.2 | 31.2 ± 19.5 |
| Morphological cancer type (I-IIa/IIb/IIc-III/Ad) | 0 | 0/0/1/0 | 5/0/3/4 | 1/1/0/3 | 6/1/4/7 |
| With intestinal-type cancer | 0 (0) | 0/1 (0) | 12/12 (100) | 4/5 (80) | 16/18 (88.9) |
| Depth of invasion (m/sm/pm-) | 0 | 1/0/0 | 3/5/4 | 1/1/3 | 5/6/7 |
| With early cancer | - | 1 (100) | 8 (66.7) | 2 (40) | 12 (66.7) |
| Screened by transoral EGD | |||||
| Screened subjects | 751 | 257 | 435 | 264 | 1707 |
| Age (yr) | 46.0 ± 12.6 | 46.6 ± 15.4 | 60.9 ± 11.8c | 64.0 ± 11.4c | 53.5 ± 15.4 |
| Males | 247 (32.9) | 95 (37.0) | 203 (46.7) | 110 (41.7) | 655 (38.4) |
| Smokers | 167 (22.2) | 39 (15.2) | 102 (23.4) | 46 (17.4) | 354 (20.7) |
| Subjects with gastric neoplasia/DR | 0/0 | 8/0.0311c | 18/0.0414c | 6/0.0227 | 32/0.0187 |
| Location of neoplasia (U/M/L) | 0 | 4/1/3 | 6/7/5 | 2/0/4 | 12/8/12 |
| Adenoma cases/DR | 0/0 | 2/0.00778 | 3/0.00689 | 4/0.0152 | 9/0.0052 |
| Size of adenoma (mm) | 0 | 7.5 ± 3.53 | 8.0 ± 13.9 | 10 ± 4.08 | 10.8 ± 7.9 |
| Cancer cases/DR | 0/0 | 6/0.0233 | 15/0.0345 | 2/0.00758 | 23/0.0134 |
| Size of cancer (mm) | 0 | 31.4 ± 12.1 | 19.4 ± 12.5 | 20 ± 0 | 22.3 ± 12.8 |
| Morphological cancer type (I-IIa/IIb/IIc-III/Ad) | 0 | 0/0/3/3 | 6/0/7/2 | 0/0/2/0 | 6/0/12/5 |
| With intestinal-type cancer | 0 (0) | 2/6 (33.3) | 12/15 (80) | 1/2 (50) | 16/24 (66.7) |
| Depth of invasion (m/sm/pm-) | 0 | 2/1/3 | 11/2/2 | 2/0/0 | 15/3/5 |
| With early cancer | - | 3 (50) | 13 (86.7) | 2 (100) | 18 (78.3) |
a
P < 0.05 vs transoral;
c
P < 0.05 vs previous stage. H. pylori: Helicobacter pylori; DR: Detection rate; U: Upper third of the stomach; M: Middle third of the stomach; L: Lower third of the stomach; EGD: Esophagogastroduodenoscopy. Group A: H. pylori (-), chronic atrophic gastritis (CAG) (-); Group B: H. pylori (+), CAG (-); Group C: H. pylori (+), CAG (+); Group D: H. pylori (-), CAG (+).