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Concordance of pncA gene analysis and PZA susceptibility testing by the BACTEC MGIT 960 method
| pncA gene mutation | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | ||
|---|---|---|---|---|---|---|
| PZA susceptibility | Yes | |||||
| Overall, n = 66 | 80.6 | 96.7 | 96.7 | 80.6 | ||
| Resistance | 29 | 7 | ||||
| Susceptible | 1 | 29 | ||||
| Beijing strain, n = 37 | 76.2 | 93.8 | 94.1 | 75 | ||
| Resistance | 16 | 5 | ||||
| Susceptible | 1 | 15 | ||||
| Non-Beijing strain, n = 29 | 86.7 | 100 | 100 | 87.5 | ||
| Resistance | 13 | 2 | ||||
| Susceptible | 0 | 14 | ||||
PZA, pyrazinamide; PPV, positive predictive value; NPV, negative predictive value.
