Table 3.

Identification of SNPs in the IRS2 gene with MAF ≥0.01 in 934 Hispanic children enrolled in Viva La Familia cohort

	SNP ID	Position on Chr 13	Left Flank. Right Flank	Major Allele	Minor Allele	MAF	Type	Reference AA	Variable AA	Protein Position	Reference Codon	Codon Position
1	rs1034104	109203128	TGGATGCACG.ACAAATGTTT	G	C	0.129	3′UTR
2	rs9587979	109203242	TTTCTTCTTT.TATTCTTGAT	G	A	0.011	3′-UTR
3	rs41275080	109204832	ATACCACCCA.TGATGCCTAT	T	C	0.015	3′-UTR
4	10467453_203	109205580	TTTTTCTTTT.GTTTTTTTTG	T	G	0.252	3′-UTR
5	10467453_204	109205581	TTTTCTTTTT.TTTTTTTTGT	G	T	0.025	3′-UTR
6	rs1044364	109205647	AATACGTTTT.TAAAAATCAA	T	C	0.096	3′-UTR
7	rs2289047	109205816	ACATCTACAT.GAGAAGATTA	C	A	0.46	3′-UTR
8	rs2289046	109205907	CCCAATACAG.TGATTTTCAA	T	C	0.366	3′-UTR
9	rs7320328	109206094	TGGACCATTT.AATAAGGCCG	C	A	0.015	3′-UTR
10	rs1865434	109206609	TTTAATGATA.TCTCTGACAT	T	C	0.083	3′-UTR
11	rs9515119	109207337	TCAAACTTTC.TATGTTCCAG	A	C	0.448	intron
12	rs754204	109209569	CACGGTAAAG.GAGAACTGTG	G	A	0.399	intron
13	rs913949	109209797	GGAAAAGGCT.GAGCACACCT	A	G	0.211	intron
14	rs12584136	109217355	AGACATTTTC.AATGCTCATG	C	A	0.094	intron
15	rs9559646	109217405	CCCAGATCTG.GAAATGCTTT	G	A	0.351	intron
16	rs9521509	109219452	CTCAATGGTA.CTCAGCGTCT	G	A	0.463	intron
17	rs4773088	109219885	CTTAACATCT.TAAGACCGGC	G	A	0.219	intron
18	rs2241745	109220532	GGGGCTGTGG.TGGCAGGAAA	A	G	0.081	intron
19	rs7999797	109224001	CCACTCAGTA.ACACCGTCCA	G	A	0.468	intron
20	rs4771647	109225210	TTTTAACCCC.AGAGAAGAGT	A	C	0.215	intron
21	rs7981170	109229575	AAACATTACC.ACATAACCCC	G	A	0.156	intron
22	rs11618950	109232311	CCAAAAAGTG.GAGCAGTGAA	G	A	0.128	intron
23	rs1805097	109233232	TGAGGCGGCG.CCGGGCCCTG	T	C	0.441	missense mutation	Gly	Asp	1057	GGC	2
24	rs9583424	109233303	CCGGCGGCGG.GGCGGCGGCT	T	C	0.155	coding synonymous	Pro	Pro	1033	CCA	3
25	9967402_329	109233309	GCGGTGGCGG.GGCTGCAGAG	C	T	0.014	coding synonymous	Pro	Pro	1031	CCG	3
26	rs12853546	109233915	TGCGCCCCAC.GGGGAGCTCA	G	A	0.147	coding synonymous	Pro	Pro	829	CCC	3
27	rs4773092	109233954	TGTCCCCGCC.CAGGTGTAGG	G	A	0.301	coding synonymous	Cys	Cys	816	TGT	3
28	rs3742210	109234233	AGCCGCCCCC.CTCGCCGGGA	A	G	0.293	coding synonymous	Ser	Ser	723	AGC	3
29	9967406_432	109234890	CTGGGCTGGA.CCGTACTCGT	G	T	0.012	coding synonymous	Gly	Gly	504	GGC	3
30	9967410_456	109236513	CGGCCGCCCG.CCGATCACGC	C	T	0.011	5′-UTR
31	9966358_25	109237356	AGCTTCCGCC.GGGAGGGGGC	G	A	0.014	promoter
32	10510452_28	109237452	TGGGCGGCGA.CCGGGCCGTG	G	A	0.015	promoter
33	10510452_31	109237455	GCGGCGAGCC.GGCCGTGCTC	G	A	0.012	promoter
34	rs63193461	109237565	CCGTCTCCCG.CCGCATCTCC	T	G	0.13	promoter
35	10510452_201	109237625	CCGCGGCCGC.GGTTCGCGAG	G	C	0.119	promoter
36	10510452_333	109237757	GCCATTCACT.GTCAGCTTGT	T	A	0.016	promoter
37	rs3803239	109237955	CAGGGGCGTC.TCTCCCCCCA	C	G	0.116	promoter
38	9966359_243	109237983	AGGAGCACCC.CTTCCTTCCT	C	T	0.012	promoter
39	10467450_40	109238040	CCCCTTCCTT.CACAGGGGCG	C	G	0.069	promoter
40	rs4773094	109239484	CCAGACTGGG.ACAAAAGAGA	G	A	0.165	promoter

Single nucleotide polymorphism (SNP) ID in dbSNP (NCBI, build 131) or assigned ID for novel SNPs by investigators. IRS2, insulin receptor sustrate 2; MAF, minor allele frequency; UTR, untranslated region. DNA sequence in positive orientation.