Table 4.

Measured genotype analysis of SNPs identified in IRS2 with obesity- and diabetes-related traits in children

SNP	rs12857529	rs74123739	9966359_49	10510452_139	9967402_248	9967400_279	9967404_111	9966359_424	9967406_194	9967406_274
Minor allele	A	C	A	G	A	A	T	C	A	A
frequency	0.009	0.007	0.007	0.002	0.001	0.001	0.002	0.001	0.001	0.001
Type	promoter	3′-UTR	promoter	promoter	coding synon	missense mutation	missense mutation	promoter	nonsense mutation	missense mutation
Glucose	0.973	0.295	0.382	0.383	0.753	0.300	0.859	0.657	0.736	0.737
Insulin	0.507	0.081	0.057	0.020	0.685	0.333	0.129	0.727	0.687	0.453
Weight	0.006	0.037	0.006	0.001	0.102	0.129	0.351	0.033	0.104	0.362
BMI	0.014	0.029	0.004	0.001	0.105	0.103	0.084	0.031	0.108	0.437
Waist	0.018	0.025	0.004	0.0004	0.109	0.076	0.098	0.102	0.114	0.484
FFM	0.007	0.115	0.121	0.001	1.000	0.027	0.805	0.046	1.000	0.211
FM	0.024	0.008	0.008	0.001	0.073	0.063	0.245	0.006	0.077	0.610
HDL	0.621	0.792	0.847	0.061	0.00002	0.563	0.599	0.705	0.00002	0.200
Total T3	0.197	0.184	0.167	0.680	0.007	0.005	0.482	0.480	0.007	0.822
Free T3	0.199	0.518	0.420	0.240	0.006	0.002	0.117	0.153	0.006	0.672
CRP	0.038	0.783	0.626	0.033	0.028	0.770	0.009	0.606	0.029	0.778
sICAM-1	0.946	0.498	0.408	0.817	0.021	0.631	0.006	0.889	0.026	0.001
Leptin	0.343	0.049	0.024	0.050	0.360	0.068	0.031	0.010	0.354	0.881
Ghrelin	0.412	0.675	0.762	0.006	0.150	0.015	0.021	0.030	0.153	0.200

All measured genotype analysis models included age, sex, age × sex, age², and age² × sex as covariates (n = 934). Nominal P values are shown uncorrected for multiple testing. P values ≤0.01 are highlighted in boldface.