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. 2011 Sep 22;8(7):564–572. doi: 10.7150/ijms.8.564

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Atorvastatin mediated myocardium protection by inhibiting the ERSR. Protein extracted from myocardium tissues four weeks after drug administration (A) or cardiac myocytes 24 h after drug treatment (B) were separated and immunoblotted sequentially with anti-GRP78, -caspase-12 and CHOP antibodies. GAPDH was used as a control reference. Band intensity is quantified in (C) and (D). The correlation between apoptosis and GRP78 is presented in (E) and (F). *P < 0.05 compared with Model or Ang II group;^#P < 0.05 compared with sham operated (Sham) or control (Cont) group.