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. 2011 Sep 27;2011:175362. doi: 10.1155/2011/175362

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Copyright © 2011 S. Saska et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Histological photomicrographs: (a) Control group: 1 week. Bone defect filled by fibrotic tissue (white star); inflammatory infiltrate (white arrow). Hematoxylin-eosin staining (HE), scale bar (500 μm); (b) Treated group: 1 week. Bone defect filled by newly formed bone, osteoids (om), medullary spaces with mesenchymal cells (ms), and several blood vessels (v); mature bone (B); BC-HA membrane (black star); inflammatory infiltrate (I) (HE), scale bar (500 μm); (c) Control group: 4 weeks. New formed bone tissue is observed with several osteocytes (black arrows), blood vessels (arrow heads), and medullary spaces (stars); bone defect is not filled completely (white star) (HE), scale bar (100 μm); (d) Treated group: 4 weeks. BC-HA membrane (star), periosteum (P), osteoblasts (white arrow), osteocytes (arrow heads), and bone matrix (blue arrow) (HE), scale bar (100 μm); (e) Control group: 16 weeks. Mature bone (HE), scale bar (200 μm). (f) Treated group: 16 weeks. BC-HA membrane (star); bone defect completely repaired by mature bone, osteocytes (black arrows), and blood vessels (arrow head) (HE), scale bar (200 μm).