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. Author manuscript; available in PMC: 2011 Sep 27.
Published in final edited form as: Magn Reson Med. 2010 Nov;64(5):1274–1280. doi: 10.1002/mrm.22553

Figure 4.

Figure 4

Biodistribution results of 153/NatGd-DOTA (□), 153/NatGd-DTPA (graphic file with name nihms322126ig1.jpg) and 153/NatGd-DTPA-BMA (■) in selected tissues of control (a) and RI (b) mice at 7 days. Please note the scale differences in the y-axes. Asterisks denote statistical significance (* = p < 0.05, ** = p < 0.01, *** = p < 0.001). Based upon this comparison of the radiotracers, it is observed that 153/NatGd-DTPA-BMA demonstrated the greatest instability generating more tissue associated activity. The magnitude of the tissue associated activity increases significantly in the renally impaired animals and demonstrates how renal impairment may magnify the effects of Gd-chelate instability.