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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Mol Microbiol. 2011 Jul 28;81(5):1190–1204. doi: 10.1111/j.1365-2958.2011.07742.x

Figure 9. Transcription activation of cpxP by protein acetylation: a model.

Figure 9

Glucose (Glc) and lactate (Lac) are converted to pyruvate (Pyr), which is converted to AcCoA by the enzyme complex pyruvate dehydrogenase (PDH). AcCoA is interconverted with acetate by the Pta-Acka pathway, with acetyl phosphate (AcP) as an intermediate (Wolfe, 2005). AcCoA serves as an acetyl-donor to the acetyltransferase YfiQ, which is required for acetylation of several sites on RNAP, including K298 on α, which is required for CpxA-independent activation of cpxP transcription.