Table 4.

Prediction accuracies of the pathway-based classifiers

Pathway	blood.acc*	liver.acc**
PIP3 signaling in B lymphocytes	81.1	78.9
Toll-like receptor (TLR) ligands and common TLR signalling pathway leading to cell proinflammatory response ***	78.6	83.6
Regulation of Apoptosis by Mitochondrial Proteins ***	78.3	88.1
Cytoplasm/mitochondrial transport of proapoptotic proteins Bid, Bmf and Bim	78.3	72.3
Role of IAP-proteins in apoptosis	78.3	82.4
VEGF-family signaling	78.0	64.2
Leukocyte chemotaxis	78.0	78.6
Angiotensin signaling via STATs	77.7	77.4
Receptor-mediated axon growth repulsion	77.7	79.6
Immune response BCR pathway	77.7	80.8
Membrane trafficking and signal transduction of G-alpha (i) heterotrimeric G-protein	77.4	66.7
Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway ***	76.7	89.3
G-Protein alpha-12 signaling pathway	76.1	70.4
Brca1 as transcription regulator	76.1	73.6
CXCR4 signaling via second messenger	76.1	78.9
G-Protein alpha-i signaling cascades	76.1	70.4
Caspases cascade	75.8	76.4
Apoptotic TNF-family pathways	75.8	80.2
CCR3 signaling in eosinophils	75.8	71.7
FAS signaling cascades	75.5	77.4
Activation of PKC via G-Protein coupled receptor	75.5	74.2
Galactose metabolism	75.5	60.1
Heme metabolism	75.5	81.4
G-Proteins mediated regulation p38 and JNK signaling	75.2	75.5
ChREBP regulation pathway	75.2	69.8
TPO signaling via JAK-STAT pathway	75.2	75.8
Angiotensin signaling via beta-Arrestin	75.2	74.5
PDGF signaling via STATs and NF-kB	75.2	79.6
Angiotensin activation of ERK	74.8	74.8
Angiotensin signaling via PYK2	74.8	76.7

^*Blood.acc is the internal cross validation accuracy based on the entire blood data set (see Methods);

^**Liver.acc is the accuracy of the blood classifiers to predict the liver based on Line 0 in Figure 2a;

^***Top three pathways using the blood to predict the liver are highlighted