Skip to main content
. Author manuscript; available in PMC: 2012 Sep 8.
Published in final edited form as: J Med Chem. 2011 Aug 11;54(17):6117–6124. doi: 10.1021/jm200757g

Figure 4.

Figure 4

Effect of the taccalonolides on mitotic spindles. HeLa cells were treated for 18 h with vehicle (A), 12 nM paclitaxel (B), 3.5 µM taccalonolide A (C), 0.8 µM taccalonolide B (D), 2.5 µM taccalonolide E (E), 1.3 µM taccalonolide N (F), 57 µM taccalonolide R (G), 3.5 µM taccalonolide T (H), 0.6 µM taccalonolide Z (I), 0.32 µM taccalonolide AA (J) or 13.5 µM taccalonolide AB (K). The microtubule structures in mitotic cells were visualized by indirect immunofluorescence using a β-tubulin antibody.