Table 1.
Antiproliferative potency of taccalonolides
| Taccalonolide | IC50 (nM) |
|---|---|
| Taccalonolide A | 594 ± 43 |
| Taccalonolide B | 190 ± 3 |
| Taccalonolide E | 644 ± 10 |
| Taccalonolide N | 247 ± 16 |
| Taccalonolide R | 13,144 ± 1,390 |
| Taccalonolide T | 335 ± 24 |
| Taccalonolide Z | 120 ± 7.5 |
| Taccalonolide AA | 32.3 ± 1.9 |
| Taccalonolide AB | 2,767 ± 107 |
| Paclitaxel | 1.2 ± 0.1 |
The concentration of each drug that causes 50% inhibition of cellular proliferation (IC50) after 48 h treatment was measured using the SRB assay (n=3–5).
IC50 values for taccalonolides A, E, B and N are from Risinger et al., 2008 17.