Table 2.

Assessments, PD-MCI criteria and cognitive profiles.

Author, Year	Domains (Tests) Assessed	Depression Scale	MCI Definition	Subjective Impairment Required	Cognitive Profile Found
Aarsland et al., 200928	Verbal Memory (California Verbal Learning Test II, total immediate recall, short-delay and long-delay free recall) Visuospatial Ability (VOSP Silhouette & Cube Subtests Attention, Executive Function (Animal Names, MMSE Serial 7s, Stroop Color-Word Test)	MADRS	≥ 1.5 SD below the z- score in at least one of three domains	No	Total MCI: 18.9%  86.5% SD   62.2% non-amnestic MCI-SD   24.3% amnestic MCI-SD  13.5% MD   2.7% non-amnestic MCI-MD   10.8% amnestic MCI-MD
Foltynie et al., 200434	Executive function (Animal fluency and FAS fluency; modified Tower of London task) Spatial Memory (CANTAB Spatial Recognition Subtest) Pattern Recognition Memory (CANTAB Pattern Recognition Memory Subtest)	No Depression Scale	≥ 1 SD below the normative data in at least one test	No	Total MCI: 35.2%  58.0% SD   34.0% fronto-striatal deficits-SD   24% temporal lobe deficits-SD  42.0% fronto-striatal & temporal deficits-MD
Hoops et al., 200940	Memory (Hopkins Verbal Learning Test, at least one of two measures impaired) Executive Function (Tower of London) Attention (Backward digit span) Visuospatial (Cube Copying)	GDS-15	≥ 1.5 SD below the normative data on tests on at least two cognitive domains112	Yes and preserved Independent Activities of Daily Living	Total MCI: 20.0% MCI Subtypes not described
Mamikonyan et al., 200947	Memory (Hopkins Verbal Learning Test-Revised, abnormal if impaired in two of three components: immediate free recall total score, retention percentage and recognition) Executive Function (Stroop Color-Word Test; the Tower of London; semantic verbal fluency) (abnormal if impairment in 2 of the 3 tests) Attention (Digit Span)	Inventory of Depression Symptomatology	≥ 1.5 SD below the normative data in at least one domain	No	Total MCI: 29.2%  61.3% SD   29% attention-SD   19.3% amnestic-SD   13% executive--SD  38.7% MD
Muslimovic et al., 200513	Executive function (Trails A and B, Stroop Color-Word Test, Tower of London- Drexel test, modified Wisconsin Card Sorting Test) WAIS-R digit symbol test, Control Word Association Test, category fluency, WAIS-III similarities) Memory (Auditory Verbal Learning Test, Rivermead Behavioral Memory Test, Logical Memory Test, Wechsler Memory Scale III, Visual Association Test) Attention (WAIS-R digits forward and backward) Language (Boston Naming Test) Visuospatial and constructive function (Judgment of Line Orientation, Groningen Intelligence Test-spatial subtest, Clock Drawing Test)	Hospital Anxiety and Depression Scale	≥2 SD below the normative data on ≥3 neuropsychological tests	No	Total Impaired: 23.5% MCI subtypes not described (reported overall % of impaired tests)
Pai et al., 2001 53	Memory (Cognitive Ability Screening Instrument, CASI subtest) Executive Function (CASI subtest) Attention (CASI subtest) Language (CASI subtest) Visuospatial (CASI subtest)	No Depression Scale	≥ 1.5 SD below the mean in at least one subtest	No	Total MCI: 38.2% MCI subtypes not described (reported overall % of impaired tests)
Prospective Author, Year	Domains (Tests) Assessed	Depression Scale	MCI Criteria	Subjective Impairment Required	Cognitive Profile Found
Janvin et al., 2006 16	Short Term Visual Memory (Benton Visual Retention Test) Visuospatial Abilities (Judgment of Line Orientation test) Executive Function (Stroop Color-Word Test)	BDI	≥ 1.5 SD below control group in at least one test		Total MCI: 52.8% b  60.5% SD b   44.7% non-amnestic-SD b (26.3% executive-SD; 18.4% visuospatial-SD)   15.8% amnestic-SD b  39.5%-MD b
Author, Year	Domains (Tests) Assessed	Depression Scale	MCI Definition	Subjective Impairment Required	Cognitive Profile Found
Williams-Gray et al, 200768	Executive (Animal Fluency & FAS Fluency, Tower of London) Pattern Recognition Memory (CANTAB Pattern Recognition Memory Subtest) Visuospatial (copy of the MMSE pentagon) Spatial Memory (CANTAB Spatial Recognition Memory Subtests)	BDI	≥ 1 SD below the control group on at least one test	No	Total MCI: 57.1% MCIf fronto-striatal-SD (“predominant”)

BDI: Beck Depression Inventory; MADRS: Montgomery and Asberg Depression Rating Scale; GDS: Geriatric Depression Scale; VOSP: Visual Object and Spatial Perception Battery; MMSE: Mini Mental Status Exam; WAIS-R: Weschler Adult Intelligence Scale-Revised; WMS: Wechsler Memory Scale; WCST: Wisconsin Card Sorting Test; COWAT: Controlled Oral Word Association Test; CANTAB: Cambridge Neuropsychological Test Automated Battery; FAS Fluency: A test of fluency for words starting with F, A, & S;

^*Subset of the PANDA: Parkinson Neuropsychometric Dementia Assessment. Subjects with MCI were categorized as “Single Domain Only” (cognitive impairment in a single domain, SD), “Multiple Domain” (cognitive impairment in two or more cognitive domains, MD), and “Overall Impairment” (sum of patients who had either single-or multiple- domain cognitive impairment);

^bat baseline;

^fat follow-up.