Table 1.
Characteristics of the cohort by severity of pelvic organ prolapse (POP).
| Variable | Moderate-to-Severe POP 7.56% (1,192) | Absent-to-Minimal POP 92.44% (14,568) | Total n=15,760 | P value |
|---|---|---|---|---|
| Age at study entry | 64.76 ± 6.74 | 62.92 ± 7.09 | 63.06 ± 7.08 | <0.001 |
| Race | ||||
| White | 82.21 (980) | 84.31 (12,250) | 84.15 (13,230) | 0.056 |
| Black | 4.45 (53) | 7.12 (1,034) | 6.91 (1,087) | <0.001 |
| Asian | 5.20 (62) | 1.94 (282) | 2.19 (344) | <0.001 |
| Hispanic | 6.29 (825) | 5.16 (750) | 5.25 (825) | 0.093 |
| History of late menarche a | 9.66 (115) | 10.86 (1,576) | 10.77 (1,691) | 0.201 |
| History of regular menses | 84.36 (1,003) | 83.93 (12,144) | 83.96 (13,147) | 0.697 |
| Nulliparous b | 1.94 (23) | 10.77 (1,562) | 10.10 (1,585) | <0.001 |
| Age at menopause (years) | 50.10 ± 4.36 | 49.48 ± 4.38 | 49.52 ± 4.38 | <0.001 |
| Early menopause c | 14.99 (155) | 18.34 (2,283) | 18.09 (2,438) | 0.007 |
| History of smoking d | 42.22 (499) | 51.13 (7,397) | 50.46 (7,896) | <0.001 |
| History of previous fracture | 15.66 (174) | 12.60 (1,674) | 12.83 (1,848) | 0.003 |
| History of thyroid disease | 20.86 (247) | 19.64 (2,841) | 19.73 (3,088) | 0.309 |
| History of emphysema | 2.99 (33) | 3.02 (397) | 3.02 (430) | 0.957 |
| History of asthma | 7.33 (86) | 6.25 (896) | 6.33 (982) | 0.146 |
| History of OCP e use (ever) | 40.86 (487) | 43.93 (6,400) | 43.70 (6,887) | 0.040 |
| History of HT f use (ever) | 13.59 (162) | 17.90 (2,608) | 17.58 (2,770) | <0.001 |
| History of falls g | 34.34 (388) | 32.72 (4,437) | 32.84 (4,825) | 0.266 |
| History of family fracture h | 42.37 (509) | 43.62 (6,354) | 43.52 (6,859) | 0.403 |
| Annual income <$50,000 | 71.86 (812) | 68.40 (9,429) | 68.66 (10,241) | 0.016 |
| BMI (kg/m2) | 29.73 ± 5.65 | 28.44 ± 5.88 | 28.53 ± 5.87 | <0.001 |
| Waist-to-Hip Ratio | .84 ± .08 | .82 ± .08 | .82 ± .08 | <0.001 |
| Calcium supplementation i | 49.50 (590) | 48.26 (7,030) | 48.35 (7,620) | 0.411 |
| Vitamin D supplementation j | 43.20 (515) | 42.52 (6,194) | 42.57 (6,709) | 0.646 |
| METS/week k | 10.66 ± 12.58 | 11.60 ± 13.67 | 11.53 ±13.59 | 0.025 |
Data are presented as mean ± standard deviation (continuous) or % (n) (categorical). P-values are calculated by Student’s t-tests for continuous variables and chi-square test for categorical variables.
Late menarche is defined as ≥ 14 years of age.
Nulliparous is defined as no prior history of live birth.
Early menopause is defined as menopause at age ≤45 years
History of smoking defined as ≥100 cigarettes ever.
History of use of oral contraceptives (ever)
History of use of hormone therapy (ever)
History of falls defined as falls within the past 12 months.
Family history of fracture defined as fracture in either or both parents after the age of 40 years.
Calcium and vitamin D supplementation defined as any vs. none.
Metabolic equivalents